Method of encapsulating biologically active materials in lipid vesicles
Patent 4235871 Issued on November 25, 1980. Estimated Expiration Date: 
February 24, 1998. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
February 24, 1998. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3804776 Method of preparing a controlled release liquid pharmaceutical composition Immunological preparations Process for the preparation of liposomes Patent #: 4089801 InventorsApplicationNo. 05/881116 filed on 02/24/1978US Classes:424/450, Liposomes264/4.6, Solid-walled microcapsule formed by physically removing a constituent (e.g., evaporation, extraction, etc.)424/196.11, Conjugate or complex includes virus or componenet thereof424/197.11, Conjugate or complex includes bacterium or component thereof or substance produced by said bacterium424/204.1, Virus or component thereof424/234.1, Bacterium or component thereof or substance produced by said bacterium (e.g., Legionella, Borrelia, Anaplasma, Shigella, etc.)424/606, Sodium containing or fluorine containing424/812, LIPOSOME COMPRISING AN ANTIBODY, ANTIBODY FRAGMENT, ANTIGEN, OR OTHER SPECIFIC OR NONSPECIFIC IMMUNOEFFECTOR424/94.3, Stabilized enzymes or enzymes complexed with nonenzyme (e.g., liposomes, etc.)424/94.6, Hydrolases (3. ) (e.g., urease, lipase, asparaginase, muramidase, etc.)428/402.2Microcapsule with fluid core (includes liposome)ExaminersPrimary: Daus, Donald G.Assistant: Eakin, M. C. Attorney, Agent or FirmInternational ClassesA61K 9/127 (20060101)C12N 9/98 (20060101) C12N 1/04 (20060101) C12N 15/87 (20060101) C12N 15/88 (20060101) AbstractThe disclosure is of a method for encapsulating biologically active materials in synthetic, oligolamellar lipid vesicles (liposomes). The method comprises providing a mixture of lipid in organic solvent and an aqueous mixture of the material for encapsulation, emulsifying the provided mixture, removing the organic solvent and suspending the resultant gel in water. The method of the invention is advantageous over prior art methods of encapsulating biologically active materials in that it provides a means for a relatively high capture efficiency of the material for encapsulation. The disclosure is also of intermediate compositions in the encapsulation method, the product vesicles, compositions including the product vesicles as an active ingredient and their use.Other References
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