3-Fluorobenzodiazepines
Patent 4232016 Issued on November 4, 1980. Estimated Expiration Date: 
November 4, 1997. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 4, 1997. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3121076 3296249 3296251 3299053 3371085 3429874 InventorsApplicationNo. 05/639163 filed on 12/09/1975US Classes:514/221, Bicyclo ring system having the seven-membered hetero ring as one of the cyclos540/497, Additional hetero atom in the additional cyclo of the tricyclo ring system540/506, Additional chalcogen bonded directly to ring carbon of the hetero ring540/510, Having -C(=X)-, wherein X is chalcogen, bonded directly to the hetero ring540/511, Halogen bonded directly to the hetero ring546/314, Carbonyl bonded directly to the six-membered hetero ring546/315, At 3-position546/316, Acyclic nitrogen bonded directly to the carbonyl546/323, Acyclic nitrogen bonded directly to the carbonyl546/328, Acyclic nitrogen attached indirectly to the six-membered hetero ring by nonionic bonding564/195, Two rings bonded directly to the same carbon in a substituent E564/217Ring in a substituent EExaminersPrimary: Jiles, Henry R.Assistant: Bond, Robert T. Attorney, Agent or FirmInternational ClassesC07D 243/24 (20060101)C07D 243/00 (20060101) Foreign Application Priority Data1974-12-20 DEAbstract3-Fluoro-2,3-dihydro-1H-1,4-benzodiazepin-2-ones of the formula ##STR1## wherein R1 is H, alkyl or fluorinated alkyl of 1-4 carbon atoms and up to 9 fluorine atoms or cycloalkylalkyl of 4-8 carbon atoms; R2 is phenyl; monohalophenyl or pyridyl; R3 is F, Cl, Br or NO2, and physiologically acceptable acid addition salts thereof, are central nervous system depressants.Other References
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