Patent References 1488097 2470906 3065139 3772431 3886265 3888976 Anticalculus composition Patent #: 4022880 InventorsApplicationNo. 05/935247 filed on 08/21/1978US Classes:424/49, DENTIFRICES (INCLUDES MOUTH WASH)424/642, For topical application514/474Ascorbic acid or derivative (e.g., vitamin C, etc.)ExaminersPrimary: Robinson, Douglas W.Attorney, Agent or FirmInternational ClassesA61K 33/30 (20060101)A61K 31/365 (20060101) AbstractA therapeutic composition is disclosed for use in improving the physiological tone of the oral tissues, which among other beneficial effects nourishes said tissues and causes them to approach normal condition. The therapeutic composition also has an antimicrobial effect on the oral microflora including those difficult to eliminate pathogenic genera known to be implicated in dental caries and periodontal disease. The therapeutic composition comprises a pharmaceutically acceptable, water soluble zinc salt and ascorbic acid or an active analog thereof. The zinc salt and the ascorbic acid are present in an amount sufficient to provide a synergistic combination which has a greater than additive antimicrobial effect on such oral genera as Actinomyces, Streptococcus, Staphylococcus, Candida, Pseudomonas and Escherichia.Field of SearchDENTIFRICES (INCLUDES MOUTH WASH) | |