Structural analogs of natural phospholipids

Patent 4221732 Issued on September 9, 1980. Estimated Expiration Date:

May 11, 1999. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Diacylglycerophosphoric acid esters of aminoethanol and methylaminoethanol and method of preparing the same
Patent #: 3960905
Issued on: 06/01/1976
Inventor: Eibl , et al.

ω-(N-acylamino)alkylphosphoryl ethanolamines, pharmaceutical compositions containing them, and their uses
Patent #: 3985875
Issued on: 10/12/1976
Inventor: Hayashi , et al.

Alpha-amino phosphonic acids Patent #: 4098849
Issued on: 07/04/1978
Inventor: Redmore , et al.

Inventors

Application

No. 06/038354 filed on 05/11/1979

US Classes:

554/41, Additional nitrogen containing558/166, Nitrogen attached indirectly to the phosphorus by acyclic nonionic bonding558/169, Chalcogen attached indirectly to the phosphorus by acyclic nonionic bonding558/170, The chalcogen, X, is in a -C(=X)- group, which group is bonded directly to the nitrogen987/224, P is pentavalent and contains the structure P-(O-C) or P-(O-Z) where Z indicates an atom other than H (9/09; 9/09A1)987/233Alchohol moiety of ester contains at least three hydroxyl functions or derivatives thereof and wherein the oxygen atoms of the derivative can be attributed to the hydroxyl functions; e.g., phosphatides, lecithin, etc. (9/10)

Examiners

Primary: Niebling, John F.

Attorney, Agent or Firm

Flocks; Karl W.

International Classes

A61K 9/127 (20060101)
C07F 9/00 (20060101)
C07F 9/10 (20060101)
C07F 9/09 (20060101)

Foreign Application Priority Data

1978-05-12 DE

Abstract

Structural analogs of natural phospholipids of the general formulae ##STR1## where R1 and R2 represent either hydrogen and/or saturated or unsaturated straight-chain and branched acyl radicals with 2 to 24 C-atoms and R3 an amino group or a substituted amino group of the formula ##STR2## and n is a number from 1-3, are useful in the preparation of stable liposomes useful as vehicles for pharmaceutical preparations.