U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Processes for the manufacture of D(-)-3-hydroxybutyric acid and D(-)-3-hydroxybutyric acid producing mutants

Patent 4211846 Issued on July 8, 1980. Estimated Expiration Date: Icon_subject August 4, 1997. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3036959

3044942

Inventor

Assignee

Application

No. 05/821858 filed on 08/04/1977

US Classes:

435/141, Propionic or butyric acid435/146, Hydroxy carboxylic acid435/441, Mutation employing a chemical mutagenic agent435/444, By use of alkylating agent (e.g., nitrosoguanidine, etc.)435/445, By use of oxidative deamination agent (e.g., nitrous acid, etc.)435/448, Ultraviolet irradiation435/822, Using bacteria or actinomycetales435/829, Alcaligenes435/831, Azotobacter435/837Bacillus megaterium

Examiners

Primary: Wiseman, Thomas G.

Attorney, Agent or Firm

International Classes

C07C 59/00 (20060101)
C07C 59/01 (20060101)
C12P 7/40 (20060101)
C12P 7/42 (20060101)
C12P 7/62 (20060101)

Foreign Application Priority Data

1976-08-04 CH

Abstract

The invention relates to a process of manufacturing D(-)-3-hydroxybutyric acid by breeding microorganisms capable of producing said acid in a nutrient medium containing certain specific carbon source; bacterial strains especially suitable in carrying out the process; an application of the process for obtaining such microorganisms; and uses of thus produced acid.

Other References

  • Harda et al., "Utilization of Alcohols by Hnnsenula miso," Agr. Biol. Chem., vol. 32, No. 9, (1968) pp. 1175-1180.
  • Yagi et al., "Studies on the Utilization of Petrochemicals by Microorganisms," Agr. Biol. Chem., vol. 33, No. 11, (1969) pp. 1587-1593.
  • Kersters et al., "The Oxidation of Glycols by Acetic Acid Bacteria," Biochem. Biophys. Acta, vol. 71, (1963) pp. 311-331.
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