Automated method and apparatus for classification of cells with application to the diagnosis of anemia
Patent 4199748 Issued on April 22, 1980. Estimated Expiration Date: 
February 3, 1998. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
February 3, 1998. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3315229 3733136 3851156 3916205 Apparatus for selectively segmenting red and white blood corpuscles contained in blood smear Method of and an apparatus for automatic classification of red blood cells Patent #: 4097845 InventorApplicationNo. 05/875126 filed on 02/03/1978US Classes:382/134, Blood cells356/39, BLOOD ANALYSIS377/10, Field of view contains plural entities or entities scanned plural times (e.g., microscopic particles)382/197, Directional codes and vectors (e.g., Freeman chains, compasslike codes)382/255Focus measuring or adjusting (e.g., deblurring)ExaminersPrimary: Boudreau, Leo H.Attorney, Agent or FirmInternational ClassesG01N 15/14 (20060101)G06K 9/00 (20060101) AbstractA method and apparatus are disclosed for measuring characteristics of cells, such as red blood cells, and for analyzing parameters of the cell characteristics to define a patient's blood. These parameters may be compared for resemblance to predetermined reference characteristic values for a blood cell pathological condition such as a specific kind of anemia or for a normal blood. A report may be generated showing such resemblance to an anemia or to a normal blood. A report may be generated showing parameters of a multivariate dispersion of distribution for a subpopulation of biconcave cells, an indication of skewness of the distribution of the cells with regard to shape variations in central pallor size; the proportion of abnormal kinds of cells found, and closeness of blood to several specific anemias. To expedite the system, a plurality of microprocessors are employed with one microprocessor controlling the imaging means and the summing of measured characteristics while one or more additional microprocessors are measureing characteristics and analyzing the digitized image signals. An improved method of measuring central pallor size is provided.Other References
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