Methods and compositions for treating viral infections and guanine acyclic nucleosides

Patent 4199574 Issued on April 22, 1980. Estimated Expiration Date:

April 22, 1997. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Inventor

Schaeffer, Howard J.

Application

No. 05/662900 filed on 03/01/1976

US Classes:

514/81, Nonshared hetero atoms in at least two rings of the polycyclo ring system514/151, Acyclic C-N=N-N containing514/263.38, Chalcogen attached indirectly to the 9- position of the purine ring system by acyclic nonionic bonding514/916, PYRETIC544/229, Boron or silicon containing544/244, Polycyclo ring system having the diazine ring as one of the cyclos544/276, Nitrogen attached directly or indirectly to the purine ring system by nonionic bonding544/277Nitrogen attached directly or indirectly to the purine ring system by nonionic bonding

Examiners

Primary: Coughlan, Paul M. Jr.

Attorney, Agent or Firm

Brown; Donald

International Classes

C07D 473/24 (20060101)
C07D 473/32 (20060101)
C07D 473/34 (20060101)
C07D 473/40 (20060101)
C07D 473/04 (20060101)
C07D 473/38 (20060101)
C07D 473/00 (20060101)
C07D 473/16 (20060101)

Foreign Application Priority Data

1974-09-02 GB

Abstract

9-Hydroxyethoxymethyl (and related) derivatives of certain 6-, and 2,6-substituted purines have been discovered to have potent anti-viral activities. Novel compounds and their pharmaceutically acceptable salts, pharmaceutical formulation containing the compounds of this invention, and the treatment of viral infections with these formulations are all disclosed. 9-(2-hydroxyethoxymethyl) guanine and 2-amino-9-(2-hydroxyethoxymethyl)adenine are examples of especially active compounds of this invention.