Immunoassay for phencyclidine

Patent 4196185 Issued on April 1, 1980. Estimated Expiration Date:

June 5, 1998. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Substituted piperidines
Patent #: 4000143
Issued on: 12/28/1976
Inventor: Dykstra , et al.

Process for preparing azo dyestuffs containing 2,4,6-tri-amino-3-(cyano ester or carbonamide)pyridine Patent #: 4038268
Issued on: 07/26/1977
Inventor: Moritz , et al.

Inventors

Assignee

Hoffmann-La Roche Inc.

Application

No. 05/912272 filed on 06/05/1978

US Classes:

436/539, Involving precipitating reagent436/542, Involving radioactive labeling436/543, INVOLVING PRODUCING OR TREATING ANTIGEN OR HAPTEN436/804, RADIOISOTOPE (E.G., RADIOIMMUNOASSAY, ETC.)436/815, TEST FOR NAMED COMPOUND OR CLASS OF COMPOUNDS530/363, Serum albumin, e.g., BSA, HSA, etc.530/389.8, Binds drug, hapten, hapten-carrier complex, or specifically-identified chemical structure (e.g., theophylline, digoxin, etc.)530/405, Nitrogen containing reactant546/234Plural carbocyclic rings containing

Examiners

Primary: Padgett, Benjamin R.
Assistant: Nucker, Christine M.

Attorney, Agent or Firm

International Classes

C07D 211/00 (20060101)
C07D 211/18 (20060101)
G01N 33/94 (20060101)

Abstract

An improved immunoassay for detecting the drug of abuse phencyclidine is described. This immunoassay is characterized in utilizing as reagents (i) an antibody elicited with a novel immunogen comprising 4-[(1-piperidinyl)cyclohexyl] benzoic acid covalently bonded to an immunogenic carrier material through the carboxyl group and (ii) a novel radiolabeled derivative of phencyclidine, namely 125 I N-(4-hydroxy-2-phenylethyl)-4-[1-(1-piperidinyl)cyclohexyl] benzamide.