Selective administration of drug with ocular therapeutic system
Patent 4186184 Issued on January 29, 1980. Estimated Expiration Date: April 23, 1999. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
A method for administering a drug to a preselected tissue compartment of the eye for advantageously controlling the concentration of drug in the tissue compartment is disclosed. The method comprises (1) placing an ocular therapeutic system in the eye, and (2) orienting the drug releasing portal of the system towards the preselected tissue compartment for controlled administration of drug thereto.
Other References
J Shell & R. Baker, Diffusional Systems for Controlled Release of Drugs to the Eye, Ann. Ophthalmol. 6:1037 (1974)
J. Shell, Ocular Therapy by Controlled Drug Delivery: the Ocusert System, Ophthalmic Surg, 5:73 (1974)
H. Armaly and K. Rao, The Effect of Pilocarpine Ocusert with Different Release Rates on Ocular Pressure, Invest. Ophthalmol. 12, 491 (1973)
V. A. Place, M. Fisher, S. Herbst, L. Gordon & R. C. Merrill, Comparative Pharmacologic Effects of Pilocarpine Administered to Normal Subjects by Eyedrops or by Ocular Therapeutic Systems, Amer. J. Ophthalmol. 80, 706 (1975), (above cited as footnotes #23-#26, p. 592)
S. K. Chandrasekaran, Harriet Benson & John Urquhart, Alza Corp., Palo Alto, Calif., Chapter 7, "Methods to Achieve Controlled Drug Delivery-The Biomedical Engineering Approach", pp. 557-572, 590-591
Robinson, J. R. Ed., "Sustained & Controlled Release Drug Delivery Systems, Marcel Dekker, Inc. N.Y., N.Y. (1978)