Enhancing tissue penetration of physiologically active steroidal agents with DMSC
Patent 4177267 Issued on December 4, 1979. Estimated Expiration Date: 
December 4, 1996. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 4, 1996. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References2942008 InventorAssigneeApplicationNo. 05/304283 filed on 11/06/1972US Classes:514/169, Cyclopentanohydrophenanthrene ring system DOAI514/772, DESIGNATED ORGANIC NONACTIVE INGREDIENT CONTAINING OTHER THAN HYDROCARBON514/936DMSO CONTAININGExaminersPrimary: Rose, Shep K.Attorney, Agent or FirmInternational ClassesA61K 8/46 (20060101)A61K 38/28 (20060101) A61K 47/20 (20060101) A61K 8/30 (20060101) A61K 31/429 (20060101) A61K 31/43 (20060101) AbstractA method of enhancing tissue penetration of physiologically active steroidal agents by conjointly applying them to the tissue with dimethyl sulfoxide. Penetration of the skin and the mucous membranes of the body cavities by these agents may be enhanced by conjoint application of such agents and dimethyl sulfoxide directly to such membranes. Preferably, for penetration of these agents through the skin compositions of DMSO at concentrations of 50% and above are employed and for penetration through mucous membranes, compositions including DMSO at concentrations of 10% and above are employed. Steroidal agents may be advantageously administered by injection with DMSO in concentrations preferably up to 20% by weight to enhance penetration of internal tissue membrane barriers to achieve better distribution of these agents.Other References
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