U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Osmotic bursting drug delivery device

Patent 4177256 Issued on December 4, 1979. Estimated Expiration Date: Icon_subject November 29, 1997. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Inventors

Assignee

Application

No. 05/855605 filed on 11/29/1977

US Classes:

424/427, Ocular424/432, IUD or ring424/473, With porous, perforated, apertured, or sieved layer (e.g., dialyzing layer, microporous layer, etc.)604/892.1Osmotic or diffusion pumped device or system

Examiners

Primary: Rose, Shep K.

Attorney, Agent or Firm

International Classes

A61K 9/00 (20060101)
A61F 6/00 (20060101)
A61F 9/00 (20060101)
A61F 6/14 (20060101)

Abstract

A drug delivery for administering drug to an aqueous body environment at a substantially constant rate. The devices consist essentially of a mixture of drug of specific average particle size dispersed in a polymer of specific water permeability, tensile strength, and Young's modulus in specific volume proportions such that the particles are surrounded substantially individually by the polymer. The constancy of the release rate of drug from the devices is governed by the drug particle size and volume proportion of drug in the mixture.

Other References

  • Ellis and Smith Handbook of Ocular Therapeutics and Pharmacology, 3rd Ed. 1969, C. V. Mosby, St. Louis, Mo., pp. 171, 172, 192, 193
  • Physician's Desk Reference for Ophthalmology 1976/1977 ed. p. 85, Medical Economics Co., Oradell, N.J
  • Narkis et al., J. Applied Polymer Sci., 20:3431-3436 (1976), "Slow Release of Water-Soluble Salts from Polymers"
  • Marson J. Appl. Chem., 1969, vol. 19, Apr., pp. 93-99, Antifouling Paints, "I. Theoretical Approach to Leaching of Soluble Pigments from Insoluble Paint Vehicles"
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