Phosphinylalkanoyl prolines

Patent 4168267 Issued on September 18, 1979. Estimated Expiration Date:

October 23, 1998. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Azetidine-2-carboxylic acid derivatives
Patent #: 4046889
Issued on: 09/06/1977
Inventor: Ondetti , et al.

Carbamate-phosphonates, and process of preparation Patent #: 4077964
Issued on: 03/07/1978
Inventor: Lecolier , et al.

Inventor

Petrillo, Jr., Edward W.

Assignee

E. R. Squibb & Sons, Inc.

Application

No. 05/953711 filed on 10/23/1978

US Classes:

548/413, Phosphorus attached indirectly to the five-membered hetero ring by nonionic bonding558/98, And carbon bonded directly to the phosphorus in the phosphorus containing reactant (e.g., methyl phosphonodichloride, etc.)562/24, The chalcogen is in a -C(=X)- group987/105, N atom of ring is bonded directly to a P atom or indirectly to a P atom other than through a ring atom of the five-membered ring (9/572E)987/135, Trivalent P compound having the structure (C)-P-(N) or (C)-P(Hal) (9/48F; 9/48H)987/139, Contains two or more P atoms or contains an atom other than C, H, or the required chalcogen atom (9/48A1; 9/48A6)987/170, Pentavalent P having the structure (C)2-P(=X)(Hal) where X is chalcogen (9/34)987/173, Contains the structure (C)2-P(=X) (X-carbocyclic ring) (9/32C3; 9/32C4; 9/32C7)987/177, Contains the structure "carbocyclic ring"-P(=X) (C) (X-C) where "--" indicates that a ring carbon of the carbocyclic ring may or may not be directly bonded to the P atom (9/32A3; 9/32A4; 9/32A7)987/184, Contains the structure "carbocylic group"-P(=X) (C) (X-B) where "--" indicates that a ring carbon of the carbocyclic ring may or may not be directly bonded to the P atom (9/30A3; 9/30A4; 9/30A7)987/186, Contains a Q-(C)-P(=X) (C) (X-B) group wherein Q is a moiety containing an atom other than C or H (9/30A1; 9/30A1+U6)987/45P atom bonded to C is bonded to an O atom which is in the same ring as P (9/6571L2; 9/6571L6)

Examiners

Primary: Daus, Donald G.
Assistant: Lee, Mary C.

Attorney, Agent or Firm

International Classes

C07F 9/00 (20060101)
C07F 9/30 (20060101)
C07F 9/48 (20060101)
C07F 9/34 (20060101)
C07F 9/32 (20060101)
C07F 9/572 (20060101)
C07F 9/6571 (20060101)

Abstract

New phosphinylalkanoyl prolines which have the general formula ##STR1## wherein R1 is lower alkyl, phenyl or phenyl-lower alkyl;R2 is hydrogen, phenyl-lower alkyl or a metal ion;R3 is hydrogen or lower alkyl;R4 is hydrogen, lower alkyl, phenyl-lower alkyl or a metal ion; andN is 0 or 1,Are useful as hypotensive agents.