Azetidine-2-carboxylic acid derivatives
Carbamate-phosphonates, and process of preparation Patent #: 4077964
ApplicationNo. 05/953711 filed on 10/23/1978
US Classes:548/413, Phosphorus attached indirectly to the five-membered hetero ring by nonionic bonding558/98, And carbon bonded directly to the phosphorus in the phosphorus containing reactant (e.g., methyl phosphonodichloride, etc.)562/24, The chalcogen is in a -C(=X)- group987/105, N atom of ring is bonded directly to a P atom or indirectly to a P atom other than through a ring atom of the five-membered ring (9/572E)987/135, Trivalent P compound having the structure (C)-P-(N) or (C)-P(Hal) (9/48F; 9/48H)987/139, Contains two or more P atoms or contains an atom other than C, H, or the required chalcogen atom (9/48A1; 9/48A6)987/170, Pentavalent P having the structure (C)2-P(=X)(Hal) where X is chalcogen (9/34)987/173, Contains the structure (C)2-P(=X) (X-carbocyclic ring) (9/32C3; 9/32C4; 9/32C7)987/177, Contains the structure "carbocyclic ring"-P(=X) (C) (X-C) where "--" indicates that a ring carbon of the carbocyclic ring may or may not be directly bonded to the P atom (9/32A3; 9/32A4; 9/32A7)987/184, Contains the structure "carbocylic group"-P(=X) (C) (X-B) where "--" indicates that a ring carbon of the carbocyclic ring may or may not be directly bonded to the P atom (9/30A3; 9/30A4; 9/30A7)987/186, Contains a Q-(C)-P(=X) (C) (X-B) group wherein Q is a moiety containing an atom other than C or H (9/30A1; 9/30A1+U6)987/45P atom bonded to C is bonded to an O atom which is in the same ring as P (9/6571L2; 9/6571L6)
ExaminersPrimary: Daus, Donald G.
Assistant: Lee, Mary C.
Attorney, Agent or Firm
International ClassesC07F 9/00 (20060101)
C07F 9/30 (20060101)
C07F 9/48 (20060101)
C07F 9/34 (20060101)
C07F 9/32 (20060101)
C07F 9/572 (20060101)
C07F 9/6571 (20060101)
AbstractNew phosphinylalkanoyl prolines which have the general formula ##STR1## wherein R1 is lower alkyl, phenyl or phenyl-lower alkyl;R2 is hydrogen, phenyl-lower alkyl or a metal ion;R3 is hydrogen or lower alkyl;R4 is hydrogen, lower alkyl, phenyl-lower alkyl or a metal ion; andN is 0 or 1,Are useful as hypotensive agents.