U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Increasing the absorption rate of insoluble drugs

Patent 4151273 Issued on April 24, 1979. Estimated Expiration Date: Icon_subject June 13, 1998. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

2149005

2698822

3297804

3308217

3325362

3330727

3374146

Inventors

Assignee

Application

No. 05/915007 filed on 06/13/1978

US Classes:

514/462, Spiro ring system514/468Polycyclo ring system having the hetero ring as one of the cyclos

Examiners

Primary: Rose, Shep K.

Attorney, Agent or Firm

International Classes

A61K 9/14 (20060101)
A61K 9/20 (20060101)
A61K 9/48 (20060101)
A61K 31/34 (20060101)

Abstract

The absorption in body fluids of poorly soluble drugs is enhanced by forming a glassy solid matrix of a carrier and the drug. A solution of the drug and the carrier is formed at an elevated temperature either with or without a solvent and chilled rapidly to form a solid mass which can be ground to a powder for oral administration in a tablet or capsule.

Other References

  • Sekiguchi et al., Chem. Pharm. Bull. 9:866-872 (1961) Studies on Absorption of Eutectic Mixture
  • Sekiguchi et al., Chem. Pharm. Bull. 12:134-144 (1964) Studies on Absorption of Eutectic Mixture
  • Goldberg et al., J. Pharm. Sci. 54:1145-1148 (1965) Increasing Dissolution Rates and Gastro-Intestinal Absorption of Drugs via Solid Solutions and Eutectic Mixtures
  • Chiou et al., J. Pharm. Sci. 58(12):1505-1509, Dec. 1969, Preparation and Dissolution Characteristics of Several Fast-Release Solid Dispersions of Griseofulvin
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