Method of preparing a controlled-release pharmaceutical preparation, and resulting composition
Patent 4145410 Issued on March 20, 1979. Estimated Expiration Date: 
June 17, 1997. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
June 17, 1997. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesMethod of preparing a controlled release liquid pharmaceutical composition Patent #: 4016100 InventorApplicationNo. 05/807373 filed on 06/17/1977US Classes:424/450, Liposomes264/4.1, Liquid encapsulation utilizing an emulsion or dispersion to form a solid-walled microcapsule (includes liposome)428/402.2, Microcapsule with fluid core (includes liposome)514/789, MISCELLANEOUS (E.G., HYDROCARBONS, ETC.)987/233Alchohol moiety of ester contains at least three hydroxyl functions or derivatives thereof and wherein the oxygen atoms of the derivative can be attributed to the hydroxyl functions; e.g., phosphatides, lecithin, etc. (9/10)ExaminersPrimary: Lovering, Richard D.Attorney, Agent or FirmInternational ClassesA61K 47/24 (20060101)C07F 9/00 (20060101) C07F 9/54 (20060101) C07F 9/10 (20060101) AbstractA method of preparing a controlled-release pharmaceutical compound for oral administration, which pharmaceutical compound is subject to enzymatic hydrolysis on oral administration, which method comprises encapsulating the pharmaceutical compound with a synthetic phosphatidyl compound having a modified polarhead moiety which increases the resistance of the phosphatidyl compound to phospholipase C hydrolysis.Other References
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