U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Cyanocarboxamidines and quinazoline process

Patent 4138561 Issued on February 6, 1979. Estimated Expiration Date: Icon_subject September 30, 1997. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives Patent #: 3935213
Issued on: 01/27/1976
Inventor: Hess

Inventors

Assignee

Application

No. 05/838417 filed on 09/30/1977

US Classes:

544/284, Additional nitrogen containing unsaturated hetero ring (e.g., thiazole, etc.)540/575, The nitrogens are in the 1,4-positions of the hetero ring544/291, Nitrogen bonded directly at 2- and 4-positions544/367, Ring chalcogen in the five-membered hetero ring544/3691,3-oxazole ring or 1,3-thiazole ring (including hydrogenated)

Examiners

Primary: Coughlan, Paul M. Jr.

Attorney, Agent or Firm

International Classes

C07D 239/00 (20060101)
C07D 295/215 (20060101)
C07D 307/00 (20060101)
C07D 295/21 (20060101)
C07D 239/95 (20060101)
C07D 307/68 (20060101)
C07D 271/00 (20060101)
C07D 271/113 (20060101)
C07D 295/00 (20060101)

Abstract

Novel cyanocarboxamidines are disclosed. The new cyanocarboxamidines are particularly valuable as intermediates in the preparation of antihypertensive 4-amino-2-(4-substituted-piperazin-1-yl)-quinazolines.

Other References

  • Curd et al., J. Chem. Soc., 1759-1766 (1948)
  • Budesinsky et al., Coll. Czech. Chem. Commun., 37, 2779-2785 (1972)
  • Ried et al., Chem. Ber., 109, 2706-2715 (1976)
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