Aminoalkyl furan derivatives
Patent 4128658 Issued on December 5, 1978. Estimated Expiration Date: 
July 25, 1997. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
July 25, 1997. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References3393209 InventorsAssigneeApplicationNo. 05/818762 filed on 07/25/1977US Classes:514/471, Nitrogen containing544/144, Chalcogen bonded directly to the bicyclo ring system544/152, The additional hetero ring is five-membered544/373, The five-membered hetero ring is one of the cyclos in a bicyclo ring system544/379, The additional hetero ring is five-membered and unsaturated (e.g., thienyl piperazines, etc.)546/201, Bicyclo ring system which is indole (including hydrogenated)546/214, The additional hetero ring consists of one oxygen and four carbons548/465, Additional hetero ring, attached directly or indirectly to the bicyclo ring system by nonionic bonding548/517, Additional hetero ring, which is attached directly or indirectly to the five-membered hetero ring by nonionic bonding549/491, Nitrogen attached indirectly to the hetero ring by nonionic bonding549/496, Having -C(=X)-, wherein X is chalcogen, attached indirectly to the hetero ring by nonionic bonding564/230, Guanidines (i.e., HN=C(-HNH)-HNH, wherein substitution may be made for hydrogen only)564/30, Acyclic564/500, Sulfur attached indirectly to the amino nitrogen by nonionic bonding564/58Additional carbon bonded directly to urea nitrogenExaminersPrimary: Raymond, Richard L.Attorney, Agent or FirmInternational ClassesC07D 207/08 (20060101)C07D 207/00 (20060101) C07D 307/00 (20060101) C07D 307/64 (20060101) C07D 307/38 (20060101) C07D 307/52 (20060101) A61K 31/34 (20060101) C07D 275/00 (20060101) C07D 275/03 (20060101) Foreign Application Priority Data1976-08-04 GBAbstractCompounds of the general formula I: ##STR1## and physiologically acceptable salts thereof and N-oxides and hydrates, in which R1 and R2 which may be the same or different represent hydrogen, lower alkyl, cycloalkyl, lower alkenyl, aralkyl or lower alkyl interrupted by an oxygen atom or a group ##STR2## in which R4 represents hydrogen or lower alkyl or R1 and R2 may, together with the nitrogen atom to which they are attached, form a heterocyclic ring which may contain other heteroatoms selected from O and ##STR3## R3 is hydrogen, lower alkyl, lower alkenyl or alkoxyalkyl; X is --CH2 --, O or S;Y represents = S, = O, = NR5 or = CHR6 ;Alk denotes a straight or branched alkylene chain of 1 to 6 carbon atoms;R5 is H, nitro, cyano, lower alkyl, aryl, alkylsulphonyl, or arylsulphonyl;R6 represents nitro, arylsulphonyl or alkylsulphonyl;M is an integer from 2 to 4; andN is 1 or 2; or when X = S, or --CH2 --, n is zero, 1 or 2.These compounds have H2 -antagonist activity. Intermediates in the production thereof are also provided. |
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