ApplicationNo. 05/669589 filed on 03/23/1976
US Classes:514/562, Sulfur nonionically bonded514/400, At imidazole ring carbon514/419C=X bonded directly or indirectly by an acyclic carbon or carbon chain to ring carbon of the five-membered hetero ring (e.g., tryptophan, etc.) (X is chalcogen)
ExaminersPrimary: Schenkman, Leonard
Attorney, Agent or Firm
International ClassesA61K 38/01 (20060101)
A61K 31/415 (20060101)
AbstractTreatment of hepatic disorders, such as are characterized by hyperammonemia and portal-systemic encephalopathy, is advocated using compositions comprising keto analogs of certain essential amino acids. In the preferred embodiments, such compositions comprise the keto analogs of valine, phenylalanine, methionine, leucine and isoleucine.