Preparation of melt-sprayed spherical phenacetin granules

Patent 4086346 Issued on April 25, 1978. Estimated Expiration Date:

April 25, 1995. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

3341415

3388196

3439633

3615142

3698844

Inventors

Assignee

Bayer Aktiengesellschaft

Application

No. 720650 filed on 09/07/1976

US Classes:

514/263.31, With perservative, stabilizer, or an additional active ingredient264/5, FORMATION OF SOLID PARTICULATE MATERIAL DIRECTLY FROM MOLTEN OR LIQUID MASS (E.G., LIQUID COMMINUTING)264/13, By extrusion spraying or gravity fall through orifice264/109, FORMING ARTICLES BY UNITING RANDOMLY ASSOCIATED PARTICLES264/117, Agitating to form larger particles (i.e., accretion or agglomeration)264/123, Autogenously or by activation of dry coated particles264/319, Applying heat or pressure264/345, By a temperature change264/349, MISCELLANEOUS514/629R is hydrogen or a lower saturated alkyl of less than seven carbons

Examiners

Primary: Rose, Shep K.

Attorney, Agent or Firm

Jacobs & Jacobs

International Classes

A61K 009/16
A61K 031/52
A61K 031/165

Foreign Application Priority Data

1974-04-06 DT

Abstract

Substantially spherical granules of phenacetin are prepared by spraying liquid phenacetin which has been melted without decomposition by means of rapid passage through a melting device in which superheating is minimized. The resultant melt-sprayed granules are superior to crystalline phenacetin in the formulation of pharmaceutical tablets.

Other References

Zaputryaev et al., (1969), Transl. of "The Preparation of Phenacetin Tablets by using Liquefaction", Chem. Abstr. 71 #94721B (1969) of Khimoko-Farmatsevticheskiizhurnal 3(5): 5-54 (1969)
Zaputryaev et al., (1970), Transl. of "Use of Fusion for Preparing Two-Component Tablets Containing Sodium Salts of Organic Acids", Chem. Abstr. 73, #133970v (1970) of Khim-Farmzh 418), 23-26 (1970)
Goodhart et al., J. Pharm. Sci. 62 (1): 133-136 Jan. 1973, Design and Use of a Laboratory Extruder for Pharmaceutical Granulations
Malinowski et al., J. Pharm. Sci. 63(2): 285-288, Feb. 1974, Effect of Spheronization Process Variables on Selected Tablet Properties
Jalal et al., J. Pharm. Sci. 61(9): 1466-1468, Sep. 1972, Tablet Granulations Composed of Spherical-Shaped Particles
Woodruff et al., J. Pharm. Sci. 61(5): 787-790, May 1972, "Effect of Processing Variables on Particles Obtained by Extrusion-Spheronization Processing"
Perry et al., Chemical Engineers Handbook, McGraw-Hill (1973), pp. 10-4-10-10, McKelvey Polymer Processing, Wiley, N.Y. 1967, pp. 288-297
Weast et al., Handbook of Chem. & Physics, 50th Ed., (1969), Chem. Rubber Cleve. O pp. C74, C7