Microsealed pharmaceutical delivery device
Patent 4053580 Issued on October 11, 1977. Estimated Expiration Date: 
October 11, 1994. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
October 11, 1994. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3279996 3518340 3545439 3710795 3797485 3832458 3845761 Microsealed pharmaceutical delivery device Method for making a microsealed delivery device Patent #: 3992518 InventorsApplicationNo. 05/724688 filed on 09/20/1976US Classes:424/425, Diffusion barrier is matrix424/424, Membrane or diffusion barrier424/427OcularExaminersPrimary: Rose, Shep K.Attorney, Agent or FirmForeign Application Priority Data1975-10-23 ARAbstractThe present invention is concerned with a pharmaceutical delivery device comprising a biologically acceptable silicone polymer matrix having microsealed compartments of 10-200 microns throughout, wherein the microsealed compartments contain a pharmaceutical in a hydrophilic solvent system. The biologically acceptable silicone polymer matrix is formed by in situ cross linking of a liquid, biologically acceptable silicone polymer in an emulsion of pharmaceutical in the hydrophilic solvent system and liquid biologically acceptable silicone polymer. The biologically acceptable silicone polymer matrix is placed in a sealed or unsealed biologically acceptable polymer container. The rate of release of pharmaceutical is controlled by altering the solubility characteristics of the hydrophilic solvent system and/or the biologically acceptable polymer matrix, the rate of release being independent of the time when the ratio of the partition coefficient of the pharmaceutical between the hydrophilic solvent system and biologically acceptable silicone polymer matrix to the solubility of the pharmaceutical in the hydrophilic solvent system is between 1 and 10-4 ml/mcg. | |
