2 Alkoxyoxamoyl-pyrazines
Patent 4036837 Issued on July 19, 1977. Estimated Expiration Date: 
July 19, 1994. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
July 19, 1994. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesOxamic acid derivatives for the prevention of immediate type hypersensitivity reactions Patent #: 3966965 InventorsAssigneeApplicationNo. 669796 filed on 03/23/1976US Classes:544/336, 1,4-diazines514/826, ASTHMA544/331, Additional hetero ring which is unsaturated544/332, Chalcogen attached indirectly to the diazine ring by nonionic bonding544/405, Additional hetero ring which is unsaturated546/268.4, The additional hetero ring is five-membered having two or more ring hetero atoms of which at least one is nitrogen546/289, Nitrogen attached directly to the six-membered hetero ring by nonionic bonding546/309, Acyclic nitrogen bonded directly to a -C(=X)- group, wherein X is chalcogen548/195, The -C(=X)- group is bonded directly to the nitrogen548/253, The chalcogen, X, is in a -C(=X)- group560/9, Sulfur in acid moiety560/13, Plural nitrogens in acid moiety560/22, Additional nitrogen in acid moiety560/37, The nitrogen is not bonded directly to a ring560/42, Oxy in acid moiety560/43, The nitrogen is bonded directly to a ring and is in same side chain as ester function560/44Polycarboxylic acidExaminersPrimary: Daus, Donald G.Assistant: Tovar, Jose Attorney, Agent or FirmInternational ClassC07D 241/02AbstractAnti-allergic agents of aromatic and heterocyclic oxamic acid derivation present the following formula: ##STR1## in which A is a member selected from the group consisting of 2-thiazolyl, 2-pyridyl, 2-pyridyl-N-oxide, 6-(lower)alkyl-2-pyridyl, 3-cyano-2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 2-pyrazinyl, -naphthyl, ଲ-naphthyl, phenyl, 2,6-dichlorophenyl, and substituted phenyl moieties containing from one to three substituents in any of the 2,3,4 and 5 positions of the phenyl ring, independently selected from the group consisting of lower alkykl, lower alkylthio, lower alkylsulfinyl, lower alkoxy, hydroxy(lower)alkoxy, 2-(lower alkoxy oxalyloxy) ethoxy, benzyloxy, N-mono- and di-lower alkylamino(lower)alkoxy, halo, sulfamyl, polyhalo(lower)alkyl, carbamyl, N-lower alkylcarbamyl, nitro, mono- and di-lower alkylamino, phenylazo, carboxy, lower alkylcarbonyl, cyano, carb(lower)alkoxy, phenoxy(lower)alkoxy, lower alkoxyoxalamido and lower alkoxyoxalamidophenoxy radicals;B, when taken alone, is a member selected from the group consisting of --OH, lower alkoxy, --NH2, --NHOH, cyclohexyloxy and phenoxy; andY is a member selected from the group consisting of oxygen and when taken with B and the carbon atom to which they are attached, forms the moiety ##STR2## |
| ||||||||||||||
