Oxamic acid derivatives for the prevention of immediate type hypersensitivity reactions Patent #: 3966965
ApplicationNo. 669796 filed on 03/23/1976
US Classes:544/336, 1,4-diazines514/826, ASTHMA544/331, Additional hetero ring which is unsaturated544/332, Chalcogen attached indirectly to the diazine ring by nonionic bonding544/405, Additional hetero ring which is unsaturated546/268.4, The additional hetero ring is five-membered having two or more ring hetero atoms of which at least one is nitrogen546/289, Nitrogen attached directly to the six-membered hetero ring by nonionic bonding546/309, Acyclic nitrogen bonded directly to a -C(=X)- group, wherein X is chalcogen548/195, The -C(=X)- group is bonded directly to the nitrogen548/253, The chalcogen, X, is in a -C(=X)- group560/9, Sulfur in acid moiety560/13, Plural nitrogens in acid moiety560/22, Additional nitrogen in acid moiety560/37, The nitrogen is not bonded directly to a ring560/42, Oxy in acid moiety560/43, The nitrogen is bonded directly to a ring and is in same side chain as ester function560/44Polycarboxylic acid
ExaminersPrimary: Daus, Donald G.
Assistant: Tovar, Jose
Attorney, Agent or Firm
International ClassC07D 241/02
AbstractAnti-allergic agents of aromatic and heterocyclic oxamic acid derivation present the following formula: ##STR1## in which A is a member selected from the group consisting of 2-thiazolyl, 2-pyridyl, 2-pyridyl-N-oxide, 6-(lower)alkyl-2-pyridyl, 3-cyano-2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 2-pyrazinyl, -naphthyl, ଲ-naphthyl, phenyl, 2,6-dichlorophenyl, and substituted phenyl moieties containing from one to three substituents in any of the 2,3,4 and 5 positions of the phenyl ring, independently selected from the group consisting of lower alkykl, lower alkylthio, lower alkylsulfinyl, lower alkoxy, hydroxy(lower)alkoxy, 2-(lower alkoxy oxalyloxy) ethoxy, benzyloxy, N-mono- and di-lower alkylamino(lower)alkoxy, halo, sulfamyl, polyhalo(lower)alkyl, carbamyl, N-lower alkylcarbamyl, nitro, mono- and di-lower alkylamino, phenylazo, carboxy, lower alkylcarbonyl, cyano, carb(lower)alkoxy, phenoxy(lower)alkoxy, lower alkoxyoxalamido and lower alkoxyoxalamidophenoxy radicals;B, when taken alone, is a member selected from the group consisting of --OH, lower alkoxy, --NH2, --NHOH, cyclohexyloxy and phenoxy; andY is a member selected from the group consisting of oxygen and when taken with B and the carbon atom to which they are attached, forms the moiety ##STR2##