U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Polypeptide propoxyphene derivatives for immunoassay reagents

Patent 4025501 Issued on May 24, 1977. Estimated Expiration Date: Icon_subject May 24, 1994. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3690834

3817837

3852157

Inventor

Assignee

Application

No. 05/560079 filed on 03/20/1975

US Classes:

530/363, Serum albumin, e.g., BSA, HSA, etc.435/7.9, Assay in which an enzyme present is a label435/961, INCLUDING A STEP OF FORMING, RELEASING, OR EXPOSING THE ANTIGEN OR FORMING THE HAPTEN-IMMUNOGENIC CARRIER COMPLEX OR THE ANTIGEN, PER SE435/964, INCLUDING ENZYME-LIGAND CONJUGATE PRODUCTION (E.G., REDUCING RATE OF NONPRODUCTIVE LINKAGE, ETC.)436/543, INVOLVING PRODUCING OR TREATING ANTIGEN OR HAPTEN436/823, IMMUNOGENIC CARRIER OR CARRIER PER SE525/420, Solid polymer derived from an amino carboxylic acid or derivative; from a polyamine and a polycarboxylic acid or derivative; from at least one lactam; or from a polyamine salt of a polycarboxylic acid530/345, Chemical aftertreatment, e.g., acylation, methylation, etc.530/389.8, Binds drug, hapten, hapten-carrier complex, or specifically-identified chemical structure (e.g., theophylline, digoxin, etc.)530/405, Nitrogen containing reactant530/409, Nitrogen containing reactant530/806, ANTIGENIC PEPTIDES OR PROTEINS530/807, HAPTEN CONJUGATED WITH PEPTIDE OR PROTEIN564/346, Ether oxygen is part of the chain564/355Hydroxy, bonded directly to carbon, or ether oxygen attached directly or indirectly to the acyclic carbon or chain by acyclic nonionic bonding with no amino nitrogen between the hydroxy or ether oxygen and the aryl ring or ring system (H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal)

Examiners

Primary: Schain, Howard E.

Attorney, Agent or Firm

International Class

G01N 33/531 (20060101)

Abstract

Novel compounds are provided which are derivatives of 1,2-diphenyl-3-methyl-4-dimethylamino-2-butanol. The indicated alcohol is employed to prepare the monoester of a dibasic acid which is conjugated with an antigen for the production of antibodies which recognize both propoxyphene and its N-desmethyl metabolite in immunoassays.

Other References

  • J Am. Chem. Soc. 75, 4458-4461, (1953), Pottland et al
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