Phenethylamine antigenic conjugates, their preparation, antibodies, and use
Patent 4016146 Issued on April 5, 1977. Estimated Expiration Date: 
April 5, 1994. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
April 5, 1994. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2372066 2957808 3098693 3704282 InventorAssigneeApplicationNo. 05/531219 filed on 12/10/1974US Classes:530/405, Nitrogen containing reactant436/527, Glass or silica436/528, Carrier is organic436/530, Cellulose or derivative436/531, Carrier is synthetic resin436/543, INVOLVING PRODUCING OR TREATING ANTIGEN OR HAPTEN436/803, STABE FREE RADICALS (E.G., SPIN IMMUNOASSAY, ETC.)436/804, RADIOISOTOPE (E.G., RADIOIMMUNOASSAY, ETC.)436/816, Alkaloids, amphetamines, and barbiturates436/822, IDENTIFIED HAPTEN530/345, Chemical aftertreatment, e.g., acylation, methylation, etc.530/358, Nucleoproteins, e.g., chromatin, chromosomal proteins, histones, protamines, salmine, etc.530/363, Serum albumin, e.g., BSA, HSA, etc.530/380, Blood proteins or globulins, e.g., proteoglycans, platelet factor 4, thyroglobulin, thyroxine, etc.530/389.8, Binds drug, hapten, hapten-carrier complex, or specifically-identified chemical structure (e.g., theophylline, digoxin, etc.)536/55Plural nitrogens containingExaminersPrimary: Roberts, Elbert L.Assistant: Suyat, Reginald J. Attorney, Agent or FirmInternational ClassG01N 33/531 (20060101)AbstractAntigenic phenethylamine conjugates are produced by blocking the amine of the phenethylamine hapten with a group, coupling of the phenethylamine to a carrier, and removal of the blocking group. Specific phenethylamines useful in this invention are amphetamine, epinephrine, and norepinephrine. The antigens thus produced can be used to raise antibodies in animal bodies, the antibodies being specific to the phenethylamine compound employed. In particular, this disclosure is directed to blocked phenethylamines for production of antigens and to a process for preparing the antigens.Other References
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