Patent References 3143472 3545439 3710795 3854480 InventorsApplicationNo. 05/591443 filed on 06/30/1975US Classes:424/432, IUD or ring128/832, With contraceptive, spermacidal, or antifertility agent424/486, Synthetic polymer504/204, Having -C(=X)X-, wherein the X is chalcogen, bonded directly to the nitrogen504/254, Chalcogen bonded directly to ring carbon of the six-membered hetero ring504/305, Benzene ring attached indirectly to the nitrogen by nonionic bonding504/323, Oxygen is bonded directly to the benzene ring and is part of an acyclic chain between the benzene ring and a -C(=O)O- group (e.g., 2,4-dichlorophenoxyacetic acids, etc.)604/515To or from the female reproductory tractExaminersPrimary: Rose, Shep K.Attorney, Agent or FirmInternational ClassA61K 9/00 (20060101)AbstractA device for the controlled continuous administration of an active agent to an environment of use is disclosed. The device comprises a body of erodible agent release rate controlling material containing an agent dispersed therethrough; the rate controlling material is a hydrophobic poly(carboxylic acid) having one ionizable carboxylic hydrogen for each 8 to 12 carbon atoms, which material erodes at a controlled and continuous rate over a prolonged period of time in response to the environment by a process of carboxylic hydrogen ionization, thereby releasing the dispersed agent at a controlled rate over a prolonged period of time. | |