Drug excipient of silicone rubber
Patent 4012497 Issued on March 15, 1977. Estimated Expiration Date: 
March 15, 1994. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
March 15, 1994. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3279996 3545439 3920805 InventorAssigneeApplicationNo. 05/616001 filed on 09/23/1975US Classes:424/432, IUD or ring128/833IntrauterineExaminersPrimary: Rose, Shep K.Attorney, Agent or FirmForeign Application Priority Data1974-09-24 DTAbstractNontoxic sustained release pharmaceutical compositions containing one or more nonionic, lipophilic drugs in a cured low temperature vulcanizable (LTV) silicone elastomer excipient are prepared substantially free of toxic vulcanizing agents or drug-reactive by-products in the elastomeric material by curing with a vulcanizable composition comprisingA. a polydimethylsiloxane having vinyl groups on both ends;B. a copolymer consisting essentially of SiO2 units, (CH3)3 SiO0.5 units, Vinyl(CH3)2 SiO0.5 units; andC. a cross-linking Si-H component, consisting essentially of (CH3)3 SiO0.5 units, (CH3)2 SiO units, and CH3 HSiO units.The resultant compositions are characterized by good physical properties and a constant rate of drug release in the body over long periods of time. | |
