Dermatalogical compounds and compositions
Patent 4007271 Issued on February 8, 1977. Estimated Expiration Date: 
February 8, 1994. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
February 8, 1994. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References1935928 InventorAssigneeApplicationNo. 688616 filed on 05/21/1976US Classes:514/163, With carboxylic acid, ester or metal salt thereof514/159, Ortho-hydroxybenzoic acid (i.e., salicyclic acid) or derivative DOAI514/179, Modified C-ring (except methyl in 13-position) (e.g., double bond containing, substituted, etc.)514/533, Compound contains two or more C(=O)O groups indirectly bonded together by only conalent bonds514/544, C(=O)O attached directly through the carbon to a benzene ring514/863, Psoriasis552/271, Polycyclo ring system containing anthracene configured ring system having at least one double bond between ring members and having oxygen single bonded or any atom double bonded direct at the 9- or 10-position (e.g., anthrones, anthranois, etc.)552/290, Carbon, halogen or plural oxygens bonded directly to the anthracene configured ring system560/20, Nitro bonded to carbon in acid moiety560/66, Acylated560/71, Salicylic acid560/72, Ring in alcohol moiety560/73, Ring in alcohol moiety560/86, Esterified phenolic hydroxy560/108Esterified phenolic hydroxyExaminersPrimary: Demers, Arthur P.Attorney, Agent or FirmInternational ClassC07C 069/78Foreign Application Priority Data1971-11-26 UKAbstractMono-, di- or tri-(X,Y-substituted-benzoyl) esters of 1,8,9-trihydroxyanthracene, wherein the anthracene moiety can be substituted by methyl at the 3-position, X is halogen, hydroxy, nitro, lower-alkyl, lower-alkoxy, phenoxy, trifluoromethyl, lower-alkylcarboxy or lower-alkoxycarbonyl and Y is hydrogen or has the meaning given hereinabove for X, are prepared by reacting the appropriate 1,8,9-trihydroxyanthracene with the appropriate substituted-benzoic acid or functional derivative thereof, e.g., acid chloride, in an inert solvent, in the presence of a suitable basic catalyst, e.g., pyridine or triethylamine, and under an inert atmosphere. Pharmaceutical compositions comprising these esters are useful in treating dermatological conditions such as psoriasis and have the improvements of having substantially no undesirable staining and irritating properties.Other References
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