Patent 4002663 Issued on January 11, 1977. Estimated Expiration Date: January 11, 1994. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
560/121, Cyclopentyl in acid moiety (e.g., prostaglandins, etc.)514/826, ASTHMA549/417, Plural chalcogens bonded directly to the hetero ring549/421, Alicyclic ring bonded directly to the chalcogen556/441, Carbocyclic ring having silicon as part of one substituent and the -COO- as part of another substituent562/503Cyclopentyl (e.g., prostoglandins, etc.)
Deuterated analogs of prostaglandins have been prepared and found to display increased activity as antifertility, bronchodilator and/or bronchoconstrictor agents compared to the natural prostaglandins. The analogs are conveniently prepared by reduction of the 15-keto group and/or the 9-keto group with a deuterated reducing agent.