Novel, transient pro-drug forms of L-DOPA
Patent 3998799 Issued on December 21, 1976. Estimated Expiration Date: 
December 21, 1993. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 21, 1993. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3803120 3891696 InventorsAssigneeApplicationNo. 569009 filed on 04/17/1975US Classes:560/251, Plural nitrogens in alcohol moiety530/324, 25 or more amino acid residues in defined sequence530/325, 24 amino acid residues in defined sequence530/326, 15 to 23 amino acid residues in defined sequence530/327, 11 to 14 amino acid residues in defined sequence530/328, 8 to 10 amino acid residues in defined sequence530/329, 6 to 7 amino acid residues in defined sequence530/330, 4 to 5 amino acid residues in defined sequence530/331, Tripeptides, e.g., tripeptide thyroliberin (TRH), melanostatin (MIF), etc.560/40, Phenylalanines562/446, Di-oxy phenyl alanines930/290Polyamino acid or polypeptide with an uninterrupted series of peptide repeating unitsExaminersPrimary: Gotts, LewisAssistant: Suyat, Reginald J. Attorney, Agent or FirmAbstractThere is provided, novel, transient pro-drug forms of L-DOPA (3,4-dihydroxy-L-phenylalanine), having the formula: ##STR1## wherein n represents an integer of from 2 to 50 with respect to formula (V-A), and wherein n represents an integer of from 1 to 50 with respect to formula (V-B);R represents a hydrogen atom, an acyl group, ##STR2## --CO-pyridyl, or --CO--R3, wherein R3 is the residue of any N,N-C1 -C2 dialkylamino acid or a C4 -C6 cycloalkylamino acid; R1 represents --OH, --O-lower alkyl, --O-benzyl, or a naturally occurring protein amino acid; and R2 represents ##STR3## --CO-pyridyl, a naturally occurring protein amino acid, 3',4'-L-diacyloxy phenylalanine, or --CO-R3.These compounds are all useful in the treatment of Parkinson's Disease. |
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