-Aminoalkyl-4-hydroxy-3-alkylsulfonylmethylphenyl ketones
Patent 3976694 Issued on August 24, 1976. Estimated Expiration Date: 
August 24, 1993. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
August 24, 1993. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References3869474 InventorsApplicationNo. 596941 filed on 07/18/1975US Classes:564/344, Hydroxy or ether oxygen bonded directly to the aryl ring or ring system564/304, Of benzene ring containing compounds564/343, Processes564/358, Group VIII noble metal containing catalyst utilized564/365, Hydroxy or ether oxygen bonded directly to the aryl ring or ring system (H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal)568/31, Carbonyl containing (e.g., ketone containing, etc.)568/313, Aldehyde reacted with ketone568/337Oxy bonded directly to benzene ringExaminersPrimary: Hines, Robert V.Attorney, Agent or FirmInternational ClassA61K 31/135 (20060101)Abstract-Aminoalkyl-4-hydroxy-3-alkylsulfonylmethylbenzyl alcohols having ଲ-adrenergic stimulant activity, particularly as selected bronchodilators, are prepared from 4-hydroxyphenones by conversion to a 3-alkylsulfonylmethylphenone, bromination of these phenones and treatment of the resulting -bromo derivatives with an N-benzyl secondary amine, followed by catalytic hydrogenation to remove the benzyl groups and reduce the ketone moiety. |
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