Tyrosyl-class antigenic conjugates, their preparation and antibodies raised thereto
Patent 3975342 Issued on August 17, 1976. Estimated Expiration Date: 
August 17, 1993. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
August 17, 1993. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References3809782 InventorAssigneeApplicationNo. 451812 filed on 03/18/1974US Classes:530/363, Serum albumin, e.g., BSA, HSA, etc.424/85.1, LYMPHOKINE436/500, THYROID HORMONE TESTS (E.G., T3, T4, TBG, TSH, ETC.)436/518, INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS436/537, Signal modification or steric inhibition436/543, INVOLVING PRODUCING OR TREATING ANTIGEN OR HAPTEN436/545, Radioactive label436/547, INVOLVING PRODUCTION OR TREATMENT OF ANTIBODY436/815, TEST FOR NAMED COMPOUND OR CLASS OF COMPOUNDS436/817, Steroids or hormones436/818, Human chorionic gonadotropin436/823, IMMUNOGENIC CARRIER OR CARRIER PER SE530/307, Calcitonin; related peptides530/308, Glucagon; related peptides530/309, Secretin or gastrin; related peptides530/333, Synthesis of peptides530/345, Chemical aftertreatment, e.g., acylation, methylation, etc.530/380, Blood proteins or globulins, e.g., proteoglycans, platelet factor 4, thyroglobulin, thyroxine, etc.530/389.8, Binds drug, hapten, hapten-carrier complex, or specifically-identified chemical structure (e.g., theophylline, digoxin, etc.)530/391.9, Conjugated via a specifically-identified linking group, coupling agent, or conjugation agent530/398, Gonadatropins530/399, Hormones, e.g., prolactin, thymosin, growth factors, etc.530/401, Cytochromes, e.g., chlorophyl, orgotein, etc.530/403, Protein is identified as an antigen, e.g., immunogenic carriers, etc.530/405, Nitrogen containing reactant530/806ANTIGENIC PEPTIDES OR PROTEINSExaminersPrimary: Turner, A. A.Assistant: Fagelson, Anna P. Attorney, Agent or FirmInternational ClassG01N 33/94 (20060101)AbstractTyrosyl, thyronine, and histidyl compounds of the formulas: ##SPC1##Where R' is selected from the group consisting of --OH and --NHPp and R" is selected from the class consisting of --H and --COPp, where Pp is a polypeptide chain having from 1 to 250 peptide groups, with or without pendant groups, X is selected from the class consisting of H and I; when X is I, X' is selected from the group consisting of H and I; and n is 0 or 1, where X' is H when n is 0; are conjugated to a carrier by first forming a primary aromatic amine on the carrier, diazotizing the amine, and coupling the tyrosyl, histidyl, or thyronine through the diazo group to form a novel antigenic conjugate. This novel antigenic conjugate can be injected into an animal for production of specific antibodies which are useful in assaying for the target, particularly by radioassaying.Other References
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