1,3-Disubstituted 3-aroylpropanes and process for the preparation thereof
Patent 3951978 Issued on April 20, 1976. Estimated Expiration Date: 
April 20, 1993. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
April 20, 1993. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2997472 3210368 3732229 InventorsAssigneeApplicationNo. 352346 filed on 04/18/1973US Classes:544/360, Six-membered ring consisting of one nitrogen and five carbons (e.g., pyridine, etc.)514/821, ANTIARRHYTHMIC544/121, Piperazine ring544/130, Double bonded divalent chalcogen containing544/131, Double bonded divalent chalcogen containing544/141, Five-membered hetero ring consisting of one nitrogen and four carbons544/162, Nitrogen attached directed or indirectly to morpholine ring by nonionic bonding544/163, Cyano containing544/168, Oxygen double bonded and acyclic nitrogen bonded directly to the same carbon544/171, The oxygen is in a -COO- group544/172, Carbonyl of -COO- group bonded directly to a ring544/174, Ether containing544/175, The oxygen is in a carbonyl group544/230, Spiro544/357, Plural diazine rings544/364, At least three hetero rings containing544/372, Five-membered hetero ring consisting of one nitrogen and four carbons544/393, Acyclic nitrogen bonded directly to a -C(=X)- group, wherein X is chalcogen544/394, The other ring nitrogen has a substituent which includes chalcogen single bonded to acyclic carbon544/399, The chalcogen, X, is in a -C(=X)- group544/70, Spiro544/87, Oxygen attached directly or indirectly to a morpholine ring by nonionic bonding546/16, The spiro includes the six-membered hetero ring546/190, Having -C(=X)-, wherein X is chalcogen, attached indirectly to a piperdine ring by nonionic bonding546/208, Ring nitrogen in the additional hetero ring546/230, Cyano attached indirectly to the piperidine ring by nonionic bonding546/233, Acyclic nitrogen bonded directly to a -C(=X)- group, wherein X is chalcogen546/235, The chalcogen, X, is in a -C(=X)- group546/237, The chalcogen, X, is in a -C(=X)- group546/238, The -C(=X)- is part of a -C(=X)X- group, wherein the X's are the same or diverse chalcogens546/239, Plural carbocyclic rings containing548/524, The atom is carbon or the chain consists of carbons548/567, The nitrogen is bonded directly to -C(=X)-, wherein X is chalcogen (e.g., 2 benzamidomethyl - pyrrolidines, etc.)548/569, The nitrogen is in a substituent attached to the ring nitrogen of the five membered hetero ring548/571, The chalcogen, X, is in a -C(=X)- group (e.g., 1-phenyl -2-pyrrolidino hexanone-1, etc.)548/573, The -C(=X)X- group is in a substituent attached to the ring nitrogen of the five-membered hetero ring (e.g., beta-pyrrolidyl ethyl ester of benzoic acid, etc.)558/405, Two carbons bonded directly to the carbon of the -C(=X)- group (e.g., ketones, etc.)560/106, Ring in alcohol moiety560/163, Aromatic alcohol moiety560/250, Nitrogen in alcohol moiety other than as nitro, nitroso or isocyanate564/342, Carbonyl is part of the chain or is attached directly or indirectly to the acyclic carbon or chain by acyclic nonionic bonding with no amino nitrogen between the carbonyl and the aryl ring or ring system564/344, Hydroxy or ether oxygen bonded directly to the aryl ring or ring system564/345Halogen bonded directly to the aryl ring or ring systemExaminersPrimary: Gallagher, R.Assistant: Tovar, Jose Attorney, Agent or FirmForeign Application Priority Data1972-04-22 ITAbstract1,3-Disubstituted-3-aroylpropanes of the formula: ##EQU1## and their salts, in which Ar represents an aryl residue unsubstituted or substituted by halogen, polyhalogeno alkyl or lower alkoxy; R1 represents an hydroxy, acyloxy, carbamoyloxy, alkylcarbamoyloxy, dialkylcarbamoyloxy, aroyloxy, alkoxy, aryloxy, or cyano group or an amino group of the formula: ##EQU2## which can be the residue of a secondary amine, a tertiary amine, or of a heterocyclic amine; and ##EQU3## represents the residue of a secondary amine, a tertiary amine, or of a heterocyclic amine, have interesting properties as analgesic agents, anti-arrhythmic agents, and central nervous depressants. |
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