|6455042||Method of treating ulcerative colitis or crohn's disease by administering an antibody to댞댧 integrin|
The present invention relates to a method for treating an autoimmune disease, such ulcerative coliteis or crohns disease characterized by lymphocyte accumulation at epithelial sites. The method involves administering to a subject an effective amount of an...
|6063906||Antibodies to integrin alpha subunit|
The present invention relates to antibodies that bind to a highly charged region of the integrin 댞 subunit and its functional equivalents. The antibodies are useful in screening assays to identify agents which mimic the ligand-binding si...
|6057423||Integrin alpha subunit|
The present invention relates to a novel integrin 댞 subunit and its functional equivalents. The method for screening a molecular library to identify lead compounds which mimick the in vivo activity of an integrin 댞 chai...
|5610281||Antibodies for modulating heterotypic E-cadherin interactions with human T lymphocytes|
The invention relates to methods and compositions for modulating the heterotypic adhesion between E-cadherin expressing cells and T lymphocytes. Monoclonal antibodies which specifically bind to E-cadherin and isolated peptides which mimic the binding func...
|5594120||Integrin alpha subunit|
The present invention relates to a novel integrin 댞 subunit and its functional equivalents. The invention further includes pharmaceutical compositions containing the isolated peptides, oligonucleotides encoding the peptides, vectors cont...
|5445940||Methods and compositions for detecting and treating a subset of human patients having an autoimmune disease|
Provided are monoclonal antibodies, fragments, and derivatives thereof reactive with an epitope of the T cell receptor alpha chain variable region, V.1, on human T lymphocytes. The monoclonal antibodies are reactive with approximately 2% of CD4
|5185250||Human γ, δT cell antigen receptor polypeptides and nucleic acids|
The present invention is directed to purified polypeptides comprising the γ T cell antigen receptor (TCR) polypeptide, the δ TCR polypeptide, a γ, δ TCR complex, or a fragment thereof containing an epitope. The invention also relates to nucleic acid ...