Inventor: Willard M. Welch, Jr.

Address: Mystic, CT
No. of patents: 19
Last patent issue date: 02/07/2006

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Number	Title	Issue Date
6995159	5-HT receptor ligands and uses thereof Compounds of Formula (IC) that act as 5-HT receptor ligands and their uses in the treatment of diseases linked to the activation of 5-HT2 receptors in animals are described herein . ...	02/07/2006
6894050	5-HT receptor ligands and uses thereof Compounds of Formula (IA) that act as 5-HT receptor ligands and their uses in the treatment of diseases linked to the activation of 5-HT2 receptors in animals are described herein ...	05/17/2005
6825198	5-HT receptor ligands and uses thereof Compounds of Formula (IA) that act as 5-HT receptor ligands and their uses in the treatment of diseases linked to the activation of 5-HT2 receptors in animals are described herein. ...	11/30/2004
6323208	Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones The present invention relates to novel atropisomers of 2,3-disubstituted-(5,6)-heteroarylfused-pyrimidin-4-ones, pharmaceutical compositions containing such compounds the use of such compounds to treat neurodegenerative, psychotropic, and drug and alcohol...	11/27/2001
5962457	2,3 Disubstituted- (5,6)-heteroarylfused-pyrimidine-4-ones The present invention relates to novel compounds of the formula I, described above, and their pharmaceutically acceptable salts, and pharmaceutical compositions and methods of treating neurodegenerative and CNS-trauma related conditions....	10/05/1999
5958948	Substituted pyrazoles as CRF antagonists The compounds of the formula wherein A, R1, R3, X1, Y and Z are as defined herein, have corticotropin-releasing factor (CRF) antagonist activity. They are useful in the treatment of illnesses induced by CRF, such as stress...	09/28/1999
5705646	Substituted pyrazoles as CRF antagonists The compounds of the formula ##STR1## wherein A, R1, R3, Z and Y are as defined herein, have corticotropin-releasing factor (CRF) antagonist activity. They are useful in the treatment of illnesses induced by CRF, such as stress ...	01/06/1998
4568749	Certain 5-aryl-2-[(4-aryl)-4-hydroxybutyn-2-yl]-1,2,3,4-γ-carbolines A novel process for preparing various 2-substituted-5-aryl-1,2,3,4-tetrahydro-γ-carboline derivatives is provided, which involves (1) condensing a corresponding 2-unsubstituted compound with formaldehyde and an appropriate acetylenic derivative in the ...	02/04/1986
4556676	Antidepressant derivatives of trans-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine Novel trans-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of norepinephrine and serotonin (5-hydroxy-tryptamine), thereby alleviating ...	12/03/1985
4536518	Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine Novel cis-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of serotonin (5-hydroxy-tryptamine), thereby alleviating serotonin abnorma...	08/20/1985
4510308	Process for preparing carboline derivatives A novel process for preparing various 2-substituted-5-aryl-1,2,3,4-tetrahydro-γ-carboline derivatives is provided, which involves (1) condensing a corresponding 2-unsubstituted compound with formaldehyde and an appropriate acetylenic derivative in the ...	04/09/1985
4448732	2-Oxo-1,3-dioxol-4-ylmethyl esters of penicillanic acid 1,1-dioxide Certain novel 2-oxo-1,3-dioxol-4-ylmethyl esters of penicillanic acid 1,1-dioxide (sulbactam) hydrolyze readily in vivo to liberate the corresponding free acid. The novel esters of this invention are useful therefore as antibacterial agents and beta-lacta...	05/15/1984
4434173	Bis-esters of 4,5-di(hydroxymethyl)-2-oxo-1,3-dioxole as antibacterial agents Derivatives of 4,5-di(hydroxymethyl)-2-oxo-1,3-dioxole in which one hydroxy group has been esterified through the carboxy group of ampicillin or amoxicillin, and the other hydroxy group has been esterified through the carboxy group of sulbactam (penicilla...	02/28/1984
4277404	5-(4-Fluorophenyl)tetrahydro-2-furanol 2-Substituted-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles of the formula (I): ##STR1## and the pharmaceutically-acceptable salts thereof, wherein the hydrogen atoms in the 4a position and 9b positions are in a trans relationship to ea...	07/07/1981
4267331	Process for the production of 2-substituted pyrido[4,3-b]-indoles A process for production of certain 2-substituted-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole tranquilizing agents of the formula ##STR1## wherein X1 and Y1 are each hydrogen or fluoro; Z1 is hydrogen, ...	05/12/1981
4252812	2-Substituted-trans-5-ar yl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles 2-Substituted-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles of the formula (I): ##STR1## and the pharmaceutically-acceptable salts thereof, wherein the hydrogen atoms in the 4a position and 9b positions are in a trans relationship to ea...	02/24/1981
4224329	2-Substitute d-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles 2-Substituted-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles of the formula (I): ##STR1## and the pharmaceutically-acceptable salts thereof, wherein the hydrogen atoms in the 4a position and 9b positions are in a trans relationship to ea...	09/23/1980
4044137	2-(Phenylthiopropyl)-5-aryl-1,2,3,4-tetrahydro-γ-carbolines 2-(Phenylthiopropyl)-5-aryl-1,2,3,4-tetrahydro-γ-carboline tranquilizing agents and the preparation thereof from 5-aryl-1,2,3,4-tetrahydro-γ-carbolines....	08/23/1977
4014890	Process for preparing indole derivatives Certain indole derivatives, and especially certain 1,2,3,4-tetrahydrocarbazoles, 1,2,3,4-tetrahydro-γ-carbolines and 1,2,3,4-tetrahydropyrrolo-[3,4-b]indoles are prepared by reacting the appropriate phenylhydrazine salt and ketone in the presence of a we...	03/29/1977

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Inventor: Willard M. Welch, Jr.