Inventor: Stuart B. Rosenblum

Address: West Orange, NJ
No. of patents: 35
Last patent issue date: 09/18/2012

Number	Title	Issue Date
8268803	5, 6-ring annulated indole derivatives and use thereof The present invention relates to 5,6-ring annulated indole derivatives of the formula (I), compositions comprising at least one 5,6-ring annulated indole derivatives, and methods of using the 5,6-ring annulated indole derivatives for treating or preventing a viral i...	09/18/2012
8207170	Heterocyclic substituted piperazines with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s...	06/26/2012
8143305	2,3-substituted indole derivatives for treating viral infections The present invention relates to 2,3-Substituted Indole Derivatives, compositions comprising at least one 2,3-Substituted Indole Derivative, and methods of using the 2,3-Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related d...	03/27/2012
8017616	Heterocyclic substituted pyridine compounds with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s...	09/13/2011
RE42461	Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents Hydroxy-substituted azetidinone hypocholesterolemic agents of the formula or a pharmaceutically acceptable salt thereof, wherein: Ar1 and Ar2 are aryl or R4-substituted aryl;	06/14/2011
7902199	Heterocyclic substituted piperazine compounds with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s...	03/08/2011
7879838	Heteroaryl substituted pyrazinyl-piperazine-piperidines with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts or solvates of said compound, or of said prodrug, said compound having the general structure...	02/01/2011
7868005	Pyrazinyl substituted piperazine-piperidines with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s...	01/11/2011
7868006	Heterocyclic substituted piperazines with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s...	01/11/2011
7846946	Heteroatom-linked substituted piperidines and derivatives thereof useful as histamine Hantagonists Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt thereof, wherein: M1 and M3 are CH or N; M2 is CH, CF o...	12/07/2010
7799789	Heterocyclic substituted pyridine or phenyl compounds with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s...	09/21/2010
7786124	Heterocyclic substituted pyridine compounds with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s...	08/31/2010
7781437	Substituted heterocyclic compounds with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s...	08/24/2010
7776862	Pyridyl and phenyl substituted piperazine-piperidines with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s...	08/17/2010
7763616	Piperazine-piperidines with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s...	07/27/2010
7635705	Heteroatom-linked substituted piperidines and derivatives thereof useful as histamine Hantagonists Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt thereof, wherein: M1 and M3 are CH or N; M2 is CH, CF o...	12/22/2009
7566718	Amine-linked pyridyl and phenyl substituted piperazine-piperidines with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s...	07/28/2009
7417045	Heterocyclic substituted pyridine or phenyl compounds with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prod rug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general ...	08/26/2008
7300941	Non-imidazole compounds Disclosed are novel compounds of the formula Also disclosed are pharmaceutical compositions comprising the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such ...	11/27/2007
7238688	Piperidine compounds Disclosed are novel compounds of the formula Also disclosed are pharmaceutical compositions comprising the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such ...	07/03/2007
7220735	Benzimidazolone histamine Hantagonists Disclosed are novel compounds of the formula wherein R1 is benzimidazolone derivative, M1 and M2 are optionally substituted carbon or nitrogen, R2 includes optionally s...	05/22/2007
7105505	Benzimidazole derivatives useful as histamine H3 antagonists Disclosed are novel compounds of the formula wherein R1 is optionally substituted benzimidazolyl or a derivative thereof; R2 is optionally substituted aryl or heteroaryl; M1 and M...	09/12/2006
6951871	Indole derivatives useful as histamine H3 antagonists Disclosed are novel compounds of the formula wherein M1 is CH or N and M2 is C(R3) or N; R1 is optionally substituted indolyl or an aza derivative thereof; R2 is o...	10/04/2005
6849621	Piperidine compounds Disclosed are novel compounds of the formula Also disclosed are pharmaceutical compositions comprising the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such as, fo...	02/01/2005
6762186	Substituted imidazoles as dual histamine H1 and H3 agonists or antagonists The present invention discloses novel substituted imidazole compounds which have H3 receptor antagonist or dual histamine-H1 and H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, ...	07/13/2004
6720328	Non-imidazole compounds Disclosed are novel compounds of the formula In Formula I, M1 is carbon, M2, M3 and M4 are carbon or nitrogen and the remaining variables are as defined in the specification. A...	04/13/2004
6440989	Phenyl-substituted tricyclic inhibitors of farnesyl-protein transferase Novel phenyl-substituted tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth...	08/27/2002
6218401	Phenyl-substituted tricyclic inhibitors of farnesyl-protein transferase Novel phenyl-substituted tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth...	04/17/2001
6133291	N-(imidazolylalkyl)substituted cyclic amines as histamine-H₃ agonists or antagonists The present invention discloses novel N(imidazolylalkyl)-substituted cyclic amine compounds which have excellent histamine-H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention dis...	10/17/2000
6130229	Tricyclic compounds having activity as RAS-FPT inhibitors Compounds of Formula I: ##STR1## wherein: X1 is hydrogen, halogen, CF3, nitro, NH2 or lower alkyl; each X2 is independently selected from the group consisting of hydrogen, halogen, lower alkoxy and lower al...	10/10/2000
6100279	Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom Disclosed are compounds of Formula I ##STR1## or pharmaceutically acceptable salts or solvates thereof. Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier and an effective amount of a Compound of Formula I...	08/08/2000
5846966	Combinations of hydroxy-substituted azetidinone compounds and HMG CoA Reductase Inhibitors Hydroxy-substituted azetidinone hypocholesterolemic agents of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: Ar1 and Ar2 are aryl or R4 -substituted aryl; Ar3 is aryl or R5	12/08/1998
5767115	Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents Hydroxy-substituted azetidinone hypocholesterolemic agents of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: Ar1 and Ar2 are aryl or R4 -substituted aryl; Ar3 is aryl or R5	06/16/1998
5631365	Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents A process for preparing compounds of the formula ##STR1## wherein R and R2 are independently --OH, --O(lower alkyl) or --0-benzyl and the remaining variables are as defined in the specification, comprising (a) treating with a strong base i...	05/20/1997
5378694	Acyl and alkoxy substituted quinolines Compounds useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. The compounds are are represented by compounds of Formula 1.0: ##STR1## and their pharmaceutically acceptable salts and solvates. Pharma...	01/03/1995

PatentStorm

Quotables

PatentStorm News

Inventor: Stuart B. Rosenblum