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| Number | Title | Issue Date |
| 8367825 | Substituted pyrimidinyl oxime kinase inhibitors The present invention is directed to substituted pyrimidine compounds of formula (I): and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, d... | 02/05/2013 |
| 8314234 | Bicyclic pyrimidine kinase inhibitors The present invention is directed to novel bicyclic pyrimidine compounds of Formula (I) or a form or composition thereof and the use thereof as inhibitors of ATP-protein kinase interactions. ... | 11/20/2012 |
| 8299082 | 1,2,4-triazolylaminoaryl (heteroaryl) sulfonamide derivatives 1,2,4-Triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I), pharmaceutically acceptable salts thereof, processes for the manufacture of 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives and pharmaceutical compositions containing 1,2,4-triaz... | 10/30/2012 |
| 8153791 | Substituted pyrimidinyl oxime kinase inhibitors The present invention is directed to substituted pyrimidine compounds of formula (I): and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, d... | 04/10/2012 |
| 7888380 | 1,2,4-Triazolylaminoaryl (heteroaryl) sulfonamide derivatives 1,2,4-Triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I), pharmaceutically acceptable salts thereof, processes for the manufacture of 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives and pharmaceutical compositions containing 1,2,4-triaz... | 02/15/2011 |
| 7855205 | Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders The present invention provides pyrimidinyl substituted fused-pyrrolyl compounds of Formula (I) and pharmaceutical compositions comprising the compounds and methods of synthesis and use thereof. The compounds are kinase inhi... | 12/21/2010 |
| 7659284 | Thiazolopyridine kinase inhibitors The present invention is directed to novel thiazolopyridines, pharmaceutical compositions thereof, and the use thereof as inhibitors of ATP-protein kinase interactions. The thiazolopyridine compounds have the following Formula (I): | 02/09/2010 |
| 7655670 | 3-spirocyclic indolyl derivatives useful as ORL-1 receptor modulators The present invention is directed to novel 3-spirocyclic indolyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the ORL-1 receptor. ... | 02/02/2010 |
| 7605154 | Substituted Thiazolo [4,5-d]pyrimidines as protein kinase inhibitors The present invention is directed to novel thiazolopyrimidine compounds of Formula (I) or a form or composition thereof and the use thereof as inhibitors of ATP-protein kinase interactions. ... | 10/20/2009 |
| 7582649 | Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders The present invention is directed to novel hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula wherein all variables are as defined herein, useful in the treatment of disorders and... | 09/01/2009 |
| 7541367 | 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders The present invention is directed to novel 3-benzoimidazolyl-pyrazolopyridine compounds of formula (I): and pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of serine-threonine protein kin... | 06/02/2009 |
| 7517885 | Substituted [4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-urea compounds The present invention relates to substituted [4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-urea compounds of Formula (I) and pharmaceutically acceptable forms thereof, as α1a/α1d adrenoreceptor modulators... | 04/14/2009 |
| 7482348 | Piperazinyl substituted cyclohexane-1,4-diamines The present invention relates to piperazine substituted cyclohexane-1,4-diamine compounds of Formula (I) and pharmaceutically acceptable forms thereof, as α1a/α1d adrenoreceptor modulators for the tr... | 01/27/2009 |
| 7470711 | Piperidinyl substituted cyclohexane-1,4-diamines The present invention relates to piperidine substituted cyclohexane-1,4-diamine compounds of Formula (I) and pharmaceutically acceptable forms thereof, as α1a/α1d adrenoreceptor modulators for the tr... | 12/30/2008 |
| 7459557 | Substituted isoindole-1,3-diones The present invention relates to substituted isoindole-1,3-dione compounds of Formula (I) and pharmaceutically acceptable forms thereof, as α1a/α1d adrenoreceptor modulators for the treatment of beni... | 12/02/2008 |
| 7427625 | Substituted thiatriazaacenaphthylene-6-carbonitrile kinase inhibitors The present invention is directed to substituted thiatriazaacenaphthylene-6-carbonitrile compounds of formula (I): and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute prote... | 09/23/2008 |
| 7317031 | Substituted triazole diamine derivatives as kinase inhibitors The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder. ... | 01/08/2008 |
| 7109220 | Amino substituted pyridinyl methanone compounds useful in treating kinase disorders The present invention provides amino substituted pyridinyl methanone compounds; pharmaceutical compositions comprising the compounds and methods of synthesis thereof. The compounds, which are cyclin dependent kinase (CDK) inhibitors, can be used to treat or ameliora... | 09/19/2006 |
| 7081463 | Hydroxy alkyl substituted 1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1receptor mediated disorders The present invention is directed to novel hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula wherein all variables are as defined herein, usef... | 07/25/2006 |
| 6924302 | Substituted triazole diamine derivatives as kinase inhibitors The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder. ... | 08/02/2005 |
| 6221608 | Methods for identifying erythropoietin receptor binding protein The extracellular domain of the human erythropoietin receptor (EPO binding protein, EBP) has been expressed and overproduced in E. coli. Control of oxygen levels and pH during high density fermentation allows the production of only the protein variant wit... | 04/24/2001 |
