Inventor: Rene S. Hubert

Address: Los Angeles, CA
No. of patents: 108
Last patent issue date: 08/14/2012

Number	Title	Issue Date
8241626	Serpentine transmembrane antigens expressed in human cancers and uses thereof Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” ...	08/14/2012
8188228	Nucleic acid and corresponding protein entitled 193P1E1B useful in treatment and detection of cancer A novel gene 0193P1E1B (also designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 19...	05/29/2012
8173132	Nucleic acid and corresponding protein entitled 213P1F11 useful in treatment and detection of cancer A novel gene (designated 213P1F11) and its encoded protein, and variants thereof, are described wherein 213P1F11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 213P1F11 provides...	05/08/2012
8173381	Nucleic acid and corresponding protein entitled 85P1B3 useful in treatment and detection of cancer A novel gene (designated 85P1B3) and its encoded protein are described. While 85P1B3 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 85P1B3 provides a diagnostic...	05/08/2012
8168187	Nucleic acid and corresponding protein entitled 184P1E2 useful in treatment and detection of cancer A novel gene (designated 184P1E2) and its encoded protein, and variants thereof, are described wherein 184P1E2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 184P1E2 provides a ...	05/01/2012
8101372	Diagnosis and therapy of cancer using SGP28-related molecules The present invention relates to methods and compositions for the diagnosis and therapy of prostate cancer which utilize isolated polynucleotides corresponding to the human SGP28 gene, proteins encoded by the SGP28 gene and fragments thereof, and antibodies capable ...	01/24/2012
8053551	Serpentine transmembrane antigens expressed in human cancers and uses therefor Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” ...	11/08/2011
8039000	Nucleic acid and corresponding protein entitled 158P3D2 useful in treatment and detection of cancer A novel gene (designated 158P3D2) and its encoded protein, and variants thereof, are described wherein 158P3D2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 158P3D2 provides a ...	10/18/2011
8039603	Nucleic acid and corresponding protein entitled 121P1F1 useful in treatment and detection of cancer A novel gene (designated 121P1F1) and its encoded protein, and variants thereof, are described wherein 121P1F1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 121P1F1 provides a ...	10/18/2011
8022174	C-type lectin transmembrane antigen expressed in human prostate cancer and uses therof A novel gene (designated PC-LECTIN) that is highly overexpressed in prostate cancer and its encoded protein is described. PC-LECTIN in normal human tissues is restricted to testis, but is highly expressed in prostate cancer. Consequently, PC-LECTIN provides a diagno...	09/20/2011
8013126	84P2A9: a prostate and testis specific protein highly expressed in prostate cancer A novel gene (designated 84P2A9) and its encoded protein is described. While 84P2A9 exhibits prostate and testis specific expression in normal adult tissue, it is aberrantly expressed multiple cancers including prostate, testis, kidney, brain, bone, skin, ovarian, b...	09/06/2011
8003758	BPC-1: a secreted brain-specific protein expressed and secreted by prostate and bladder cancer cells Described is a novel gene and its encoded secreted tumor antigen, termed BPC-1, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express BPC-1, particularly including prostate cancer and bladder cancer. In ...	08/23/2011
8003100	Antibodies that bind to 238P1B2 A novel gene (designated 238P1B2) and its encoded protein, and variants thereof, are described wherein 238P1B2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 238P1B2 provides a ...	08/23/2011
7982004	Nucleic acid and corresponding protein entitled 161P5C5 useful in treatment and detection of cancer A novel gene (designated 161P5C5) and its encoded protein, and variants thereof, are described wherein 161P5C5 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P5C5 provides a ...	07/19/2011
7981624	Methods to detect tumors using 20P1F12/TMPRSS2 expression Compositions for the diagnosis and therapy of prostate and colon cancer, derived from or based on a novel prostate-specific, androgen-regulated, cell membrane associated and secreted serine protease termed 20P1F12/TMPRSS2 are described. A full length cDNA comprising...	07/19/2011
7977062	Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer A novel gene 0161P2F10B (also designated 161P2F10B) and its encoded protein, and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently,...	07/12/2011
7968283	Gene expressed in prostate cancer A novel testis-specific gene expressed in human prostate cancer, designated 22P4F11, is described. Analysis of 22P4F11 mRNA expression in normal prostate, prostate tumor xenografts, and a variety of normal tissues indicates that the expression of this gene is testis...	06/28/2011
7968307	Serpentine transmembrane antigens expressed in human cancers and uses thereof Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” ...	06/28/2011
7968099	Nucleic acid and corresponding protein entitled 193P1E1B useful in treatment and detection of cancer A novel gene (designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 193P1E1B provides...	06/28/2011
7960527	Nucleic acid and corresponding protein entitled 151P3D4 useful in treatment and detection of cancer A novel gene (designated 151P3D4) and its encoded protein, and variants thereof, are described wherein 151P3D4 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 151P3D4 provides a ...	06/14/2011
7951375	Methods of inducing an immune response Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers su...	05/31/2011
7947459	Serpentine transmembrane antigens expressed in human cancers and uses thereof Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” ...	05/24/2011
7928212	Gene upregulated in cancers of the prostate The present invention relates to a novel protein designated 20P2H8 which shares homology with several heterogeneous nuclear ribonucleoproteins (hnRNPs). A full length approximately 3600 bp 20P2H8 cDNA (SEQ ID NO: 1, encoding a 517 amino acid open reading frame (SEQ ...	04/19/2011
7928201	Serpentine transmembrane antigens expressed in human cancers and uses thereof Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” ...	04/19/2011
7928196	Nucleic acid and corresponding protein entitled 125P5C8 useful in treatment and detection of cancer A novel gene (designated 125P5C8) and its encoded protein, and variants thereof, are described wherein 125P5C8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 125P5C8 provides a ...	04/19/2011
7923543	Nucleic acid and corresponding protein entitled 162P1E6 useful in treatment and detection of cancer A novel gene (designated 162P1E6) and its encoded protein, and variants thereof, are described wherein 162P1E6 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 162P1E6 provides a ...	04/12/2011
7897740	Secreted protein called 36P6D5 characteristic of tumors Described is a gene and its encoded secreted tumor antigen, termed 36P6D5, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express 36P6D5, particularly including cancers of the bladder, kidney, prostate, b...	03/01/2011
7892548	121P1F1: a tissue specific protein highly expressed in various cancers A novel gene (designated 121P1F1) and its encoded protein are described. While 121P1F1 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including prostate, bladder, kidney, brain, bone, cervical, uterine, ova...	02/22/2011
7879570	Nucleic acid and corresponding protein entitled 184P1E2 useful in treatment and detection of cancer A novel gene (designated 184P1E2) and its encoded protein, and variants thereof, are described wherein 184P1E2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 184P1E2 provides a ...	02/01/2011
7858760	Antibodies to protein expressed in prostate cancer A novel prostate tumor associated gene (designated 24P4C12) and its encoded protein is described. 24P4C12 is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in at least some prostate cancers. 24P4C12 provides a diagnostic and/...	12/28/2010
7803916	Gene expressed in prostate cancer A novel testis-specific gene expressed in human prostate cancer, designated 22P4F11, is described. Analysis of 22P4F11 mRNA expression in normal prostate, prostate tumor xenografts, and a variety of normal tissues indicates that the expression of this gene is testis...	09/28/2010
7795391	Protein showing enhanced expression in cancer cells A novel gene (designated 101P3A11 or PHOR-1) and its encoded protein, and variants thereof, are described wherein 101P3A11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 101P3A1...	09/14/2010
7785811	BPC-1: a secreted brain-specific protein expressed and secreted by prostate and bladder cancer cells Described is a novel gene and its encoded secreted tumor antigen, termed BPC-1, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express BPC-1, particularly including prostate cancer and bladder cancer. In ...	08/31/2010
7771968	Gene upregulated in cancers of the prostate The present invention relates to a novel protein designated 20P2H8 which shares homology with several heterogeneous nuclear ribonucleoproteins (hnRNPs). A full length approximately 3600 bp 20P2H8 cDNA (SEQ ID NO: 1, encoding a 517 amino acid open reading frame (SEQ ...	08/10/2010
7759474	Nucleic acid and corresponding protein entitled 125P5C8 useful in treatment and detection of cancer A novel gene (designated 125P5C8) and its encoded protein, and variants thereof, are described wherein 125P5C8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 125P5C8 provides a ...	07/20/2010
7749746	Nucleic acid encoding 238P1B2 useful in detecting cancer A novel gene (designated 238P1B2) and its encoded protein, and variants thereof, are described wherein 238P1B2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 238P1B2 provides a ...	07/06/2010
7736654	Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers su...	06/15/2010
7732584	Nucleic acid and corresponding protein entitled 193P1E1B useful in treatment and detection of cancer A novel gene 0193P1E1B (also designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 19...	06/08/2010
7727533	Serpentine transmembrane antigens expressed in human cancers and uses thereof Described is a family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane	06/01/2010
7700749	Nucleic acid and corresponding protein entitled 205P1B5 useful in treatment and detection of cancer A novel gene (designated 205P1B5) and its encoded protein are described. While 205P1B5 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in prostrate cancer. Consequently, 205P1B5 provides a diagnostic, prognostic, prophylactic a...	04/20/2010

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Inventor: Rene S. Hubert