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President Rutherford B. Hayes ; Said in 1876, after Alexander Graham Bell demonstrated the telephone to him at the White House
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| Number | Title | Issue Date |
| 8106060 | 8-(3-amino-piperidin-1-yl)-xanthines, their preparation, and their use as pharmaceuticals The invention relates to 8-[3-amino-piperidin-1-yl]-xanthines and the physiologically acceptable salts thereof, particularly the hydrochlorides thereof. ... | 01/31/2012 |
| 8034809 | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments Enantiomerically pure compounds of general formula 1 wherein the groups R1, R2, R3, R4, and X− may have the meanings given in the claims and in the specification, pro... | 10/11/2011 |
| 7968717 | Crystalline anhydrate with anticholinergic efficacy The invention relates to a new crystalline anhydrate of tiotropium bromide, processes for preparing it and its use for preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pul... | 06/28/2011 |
| 7939658 | Enantiomeric pure beta agonists, manufacturing and use as a medicaments thereof The present invention relates to enantiomerically pure compounds of formula 1 wherein the groups m, n, B, X, R1, m and Ym− may have the meanings given in the claims and specification, methods for pre... | 05/10/2011 |
| 7932273 | 3-[(2-{[4-(hexyloxycarbonylaminoiminomethyl) phenylamino]methyl}-1-methyl-1H-benzimidazol-5-carbonyl)pyridin-2-ylamino]propionic acid ethylester methansulfonate and its use as a medicament Ethyl 3-[(2-{[4-(hexyloxycarbonylaminoiminomethyl)phenylamino]methyl}-1-methyl-1H-benzimidazole-5-carbonyl)pyridin-2-ylamino]propionate methanesulfonate in the crystalline modifications I and II and as the hemihydrate and the use thereof as a pharmaceutical composit... | 04/26/2011 |
| 7728134 | Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament Disclosed are hydrates and polymorphs of 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]Amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide: processes for preparing them and their use as pha... | 06/01/2010 |
| 7709474 | Enantiomerically pure beta agonists, manufacturing and use thereof The present invention relates to enantiomerically pure compounds of formula 1 wherein the groups R1, R2, R3, m and Ym− may have the meanings given in the claims and specificatio... | 05/04/2010 |
| 7534789 | Enantiomeric pure β agonists, manufacturing and use as a medicament thereof The present invention relates to enantiomerically pure compounds of formula 1 wherein the groups m, n, B, X, R1, m and Ym− may have the meanings given in the claims and specification, methods for pre... | 05/19/2009 |
| 7514468 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions The present invention relates to indolinone derivatives substituted in the 6 position of general formula wherein R1 to R6 and X are defined as in claim 1, the tautomers, enantiomers... | 04/07/2009 |
| 7491719 | Enantiomerically pure beta agonists, process for the manufacture thereof, and use thereof as medicaments Enantiomerically pure compounds of general formula 1 wherein the groups R1, R2, R3, R4, and X− may have the meanings given in the claims and in the specification, pro... | 02/17/2009 |
| 7439358 | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative The present invention relates to a specific salt of a dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pt... | 10/21/2008 |
| 7294721 | (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1(pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition Crystalline forms of the compounds (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1-(pyrrolidinocarbonyl)-ethyl]-benzimidazole and the monohydrochloride thereof, processes for the preparation thereof and the use thereof as pharmaceutical compo... | 11/13/2007 |
| 7220742 | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments The present invention relates to enantiomerically pure compounds of general formula 1 wherein the groups R1, R2, R3, R4 and X− may have the meanings given ... | 05/22/2007 |
| 7169934 | (R) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1 (pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition Crystalline forms of the compounds (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1-(pyrrolidinocarbonyl)-ethyl]-benzimidazole and the monohydrochloride thereof, processes for the preparation thereof and the use thereof as pharmaceutical compo... | 01/30/2007 |
| 7119093 | 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate and the use thereof as a pharmaceutical composition The present invention relates to the compound 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycabonyl-2-indolinone-monoethanesulphonate of formula I and the use thereof as a pharmaceutical composition... | 10/10/2006 |
| 6908928 | Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions Crystalline monohydrate of (1α,2β,4β,5α,7β)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide (tiotropium bromide monohydrate), processes for the preparation thereof, pharmaceutical compositions thereof,... | 06/21/2005 |
| 6869948 | Meloxicam for oral administration The invention relates in its first aspect to a rapidly decomposing tablet for pain therapy containing meloxicam [4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide] in the form of a salt with an inorganic or organic base provi... | 03/22/2005 |
| 6777423 | Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions Crystalline monohydrate of (1α,2β,4β,5α,7β)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide (tiotropium bromide monohydrate), processes for the preparation thereof, pharmaceutical compositions thereof,... | 08/17/2004 |
| 6730678 | Benzoylguanidine salt and hydrates thereof 4-[4-(2-pyrrolylcarbonyl)-1-piperazinyl]-3-trifluoromethylbenzoylguanidine hydrochloride and its hydrates, processes for preparing this benzoylguanidine salt and its hydrates, pharmaceutical compositions containing this benzoylguanidine salt and its hydrates, and it... | 05/04/2004 |
| 6608055 | Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition The invention relates to crystalline anhydrous (1,2ଲ,4ଲ,5,7ଲ)-7-[(hydroxydi-2-thienylacetyl) oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.022,4 ]nonane-bromide, processes for preparing it and its use for prepari... | 08/19/2003 |