Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 8101403 | Method and device for rapid parallel microfluidic molecular affinity assays Disclosed are methods and devices for rapid parallel molecular affinity assays performed in a microfluidic environment. The invention exploits hydrodynamic addressing to provide simultaneous performance of multiple assays in parallel using a minimal sample volume fl... | 01/24/2012 |
| 7736891 | Microfluidic assay system with dispersion monitoring Disclosed is a microfluidic assay system and methods that apply flow injection analysis to permit dispersion monitoring. A solution containing a reagent that binds an analyte and a tracer is delivered via pressure-driven flow into the receiving end of the injection ... | 06/15/2010 |
| 7659089 | Chemical sensor enhanced by direct coupling of redox enzyme to conductive surface The invention provides a method, apparatus and system for detecting electrochemical oxidoreduction activity mediated by a redox enzyme at a site remote from the enzyme. In one embodiment, the method comprises immobilizing the redox enzyme on a first region of a cond... | 02/09/2010 |
| 7550267 | Microscale diffusion immunoassay utilizing multivalent reactants An improved microscale diffusion immunoassay utilizing multivalent reactants is disclosed. In particular, a method for detecting the presence of analyte particles in an analyte fluid is disclosed, the method comprising: (a) providing the analyte fluid comprising the... | 06/23/2009 |
| 7405054 | Signal amplification method for surface plasmon resonance-based chemical detection The present invention provides methods and compositions for amplifying the detection signal in surface plasmon resonance (SPR)-based flow systems. The signal amplification methods comprise the use of well established marker systems that provide a precipitate. The ma... | 07/29/2008 |
| 7364886 | Chemical sensor enhanced by direct coupling of redox enzyme to conductive surface The invention provides a method, apparatus and system for detecting electrochemical oxidoreduction activity mediated by a redox enzyme at a site remote from the enzyme. In one embodiment, the method comprises immobilizing the redox enzyme on a first region of a cond... | 04/29/2008 |
| 7271007 | Microscale diffusion immunoassay Methods and apparatuses are provided for determining presence and concentration of analytes by exploiting molecular binding reactions and differential diffusion rates. Analyte particles and binding particles are allowed to diffuse toward each other, and slowing of t... | 09/18/2007 |
| 7258837 | Microfluidic device and surface decoration process for solid phase affinity binding assays This invention provides a microfluidic device for use in the detection of one or more analytes in a fluid using solid-phase affinity binding assays. The device offers a practical, easy-to-use, portable, inexpensive, robust analytical system for the parallel and quan... | 08/21/2007 |
| 7141429 | Use of liquid junction potentials for electrophoresis without applied voltage in a microfluidic channel This invention provides methods for using liquid junction potentials to control the transport of charged particles in fluid streams that are in laminar flow within microfluidic channels. Applications of the methods of this invention include sample preconditioning (r... | 11/28/2006 |
| 7030989 | Wavelength tunable surface plasmon resonance sensor This invention provides methods, devices and device components for sensing, imaging and characterizing changes in the composition of a probe region. More particularly, the present invention provides methods and devices for detecting changes in the refractive index o... | 04/18/2006 |
| 6790341 | Microband electrode arrays The present invention provides microband electrode array sensors for detecting the presence and measuring the concentration of analytes in a sample. The microband electrodes of the invention have both a width and thickness of microscopic dimensions. Preferably the w... | 09/14/2004 |
| 6695147 | Absorption-enhanced differential extraction device This invention provides an extraction device and a method for extracting desired particles from a sample stream containing the desired particles. The device has a sample stream inlet, an extraction stream inlet, and an extraction channel in fluid communic... | 02/24/2004 |
| 6541213 | Microscale diffusion immunoassay Methods and apparatuses are provided for determining presence and concentration of analytes by exploiting molecular binding reactions and differential diffusion rates. Analyte particles and binding particles are allowed to diffuse toward each other, and s... | 04/01/2003 |
| 6482306 | Meso- and microfluidic continuous flow and stopped flow electroosmotic mixer An electroosmotic mixing device and a method for mixing one or more fluids for use in meso- or microfluidic device applications. The mixing device provides batch or continuous mixing of one or more fluids in meso- or microfluidic channels. An electric fie... | 11/19/2002 |
| 6454945 | Microfabricated devices and methods This invention provides microfabricated systems for extraction of desired particles from a sample stream containing desired and undesired particles. The sample stream is placed in laminar flow contact with an extraction stream under conditions in which in... | 09/24/2002 |
| 6415821 | Magnetically actuated fluid handling devices for microfluidic applications Magnetically actuated fluid handling devices using magnetic fluid to move one or more fluids (gases or liquids or both) through microsized flow channels are provided. Fluid handling devices include micropumps and microvalves. Magnetically actuated slugs o... | 07/09/2002 |
| 6408884 | Magnetically actuated fluid handling devices for microfluidic applications Magnetically actuated fluid handling devices using magnetic fluid to move one or more fluids (gases or liquids or both) through microsized flow channels are provided. Fluid handling devices include micropumps and microvalves. Magnetically actuated slugs o... | 06/25/2002 |
| 6297061 | Simultaneous particle separation and chemical reaction This invention provides a method and apparatus for detecting the presence of analyte particles in a sample fluid also comprising larger particles, particularly blood. It exploits diffusion to provide simultaneous filtering of the larger particles and reac... | 10/02/2001 |
| 6277641 | Methods for analyzing the presence and concentration of multiple analytes using a diffusion-based chemical sensor The present invention provides a microfabricated sensor and a method capable of rapid simultaneous measurement of multiple analytes in a fluid sample. The sensor is inexpensive, disposable and portable, and requires only microliters of sample, a particula... | 08/21/2001 |
| 6221677 | Simultaneous particle separation and chemical reaction This invention provides a method and apparatus for detecting the presence of analyte particles in a sample fluid also comprising larger particles, particularly blood. It exploits diffusion to provide simultaneous filtering of the larger particles and reac... | 04/24/2001 |
| 6180114 | Therapeutic delivery using compounds self-assembled into high axial ratio microstructures Therapeutic complexes comprising plural therapeutic compounds self assembled into high axial ratio microstructures are described. The therapeutic complexes satisfy the formula HARM-Th, wherein HARM is a high axial ratio forming material and Th is a therap... | 01/30/2001 |
| 6159739 | Device and method for 3-dimensional alignment of particles in microfabricated flow channels The present invention provides a sheath flow module made from a first plate of material having formed therein a laminar fluid flow channel; at least two inlets, each inlet joining the laminar flow channel at a junction, the first inlet junction being wide... | 12/12/2000 |
| 6110354 | Microband electrode arrays The present invention provides microband electrode array sensors for detecting the presence and measuring the concentration of analytes in a sample. The microband electrodes of the invention have both a width and a thickness of microscopic dimensions. Pre... | 08/29/2000 |
| 6039897 | Multiple patterned structures on a single substrate fabricated by elastomeric micro-molding techniques A method for patterning a material onto a substrate including the steps of: providing a micro-mold having a plurality of non-communicating independent channels and having a plurality of reservoirs for receiving a micro-molding fluid each of which reservoi... | 03/21/2000 |
| 6007775 | Multiple analyte diffusion based chemical sensor The present invention provides a microfabricated sensor and a method capable of rapid simultaneous measurement of multiple analytes in a fluid sample. The sensor is inexpensive, disposable and portable, and requires only microliters of sample, a particula... | 12/28/1999 |
| 5972710 | Microfabricated diffusion-based chemical sensor A channel-cell system is provided for detecting the presence and/or measuring the presence of analyte particles in a sample stream comprising: a) a laminar flow channel; b) two inlets in fluid connection with the laminar flow channel for respectively cond... | 10/26/1999 |
| 5971158 | Absorption-enhanced differential extraction device This invention provides an extraction device and a method for extracting desired particles from a sample stream containing the desired particles. The device has a sample stream inlet, an extraction stream inlet, and an extraction channel in fluid communic... | 10/26/1999 |
| 5932100 | Microfabricated differential extraction device and method This invention provides a microfabricated extraction system and methods for extracting desired particles from a sample stream containing desired and undesired particles. The sample stream is placed in laminar flow contact with an extraction stream under c... | 08/03/1999 |
| 5851536 | Therapeutic delivery using compounds self-assembled into high axial ratio microstructures Therapeutic agents comprising plural therapeutic compounds self assembled into high axial ratio microstructures are described. The threapeutic compounds satisfy the formula HARFM-Th, wherein HARFM is a high axial ratio forming material and Th is a therape... | 12/22/1998 |
| 5726751 | Silicon microchannel optical flow cytometer The present invention provides a flow cytometer made of two components: a flow cytometer optical head and a disposable flow module. The flow module utilizes a V-groove flow channel micromachined in a silicon wafer. The optical head comprises a laser to pr... | 03/10/1998 |
| 5716852 | Microfabricated diffusion-based chemical sensor A channel-cell system is provided for detecting the presence and/or measuring the presence of analyte particles in a sample stream comprising: a) a laminar flow channel; b) two inlet means in fluid connection with said laminar flow channel for respectivel... | 02/10/1998 |
| 5094819 | Fluorescence-based optical sensor and method for detection of lipid-soluble analytes A sensor, probe, system and method for detecting the presence of or concentration of lipid-soluble analytes such as anesthetics, which involve the use of fluorophore-containing lipid layers or similar amphiphilic structures as the sensor. The lipid layer ... | 03/10/1992 |
| 4990291 | Method of making lipid tubules by a cooling process Diacetylinic phosophocholines have distinctly different endothermic and exothermic transition temperatures. Lipid tubules are formed by hydrating a diacetylinic phosphocholine at a temperature above its endothermic transition temperature. The hydrated lip... | 02/05/1991 |
