Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 6197800 | Benzothia(oxa)diazol derivatives and their use as endothelin-receptor antagonists Novel compounds of the formula I ##STR1## in which R is ##STR2## X is O or S, and R1, R2, R3, R4, R5 and R6 have the meaning indicated in patent claim 1, or a tautomeric ring-closed form, a... | 03/06/2001 |
| 5883090 | Endothelin receptor antagonists This invention relates to pyridizinone derivatives of formula I ##STR1## wherein the various substituents are defined in the specification, and salts thereof, which have useful pharmacological properties, in particular endothelin receptor-antagonisti... | 03/16/1999 |
| 5821256 | Endothelin receptor antagonists Novel compounds of the formula I ##STR1## in which R1, R2, R3 and X have the meaning indicated in claim 1, and their salts exhibit endothelin receptor-antagonistic properties.... | 10/13/1998 |
| 5726194 | Endothelin receptor antagonists Novel compounds of the formula I ##STR1## in which R1, R2, R3, --A.dbd.B--C.dbd.D--, Ar and X have the meaning indicated in claim 1, and their salts show endothelin receptor-antagonistic properties.... | 03/10/1998 |
| 5532276 | Imidazopyridines Novel imidazopyridine derivatives of the formula ##STR1## wherein R is ##STR2## and R1, R2, R3, R4, Ar1, X and Y are as defined in the specification, and their salts, exhibit antagonistic p... | 07/02/1996 |
| 5476857 | Imidazopyridines Novel imidazopyridine derivatives of formula I: ##STR1## wherein R is ##STR2## and R1, R2, R3, R4, X and Y are as defined herein, and their salts, exhibit antagonistic properties toward angiotensin II ... | 12/19/1995 |
| 5438063 | Imidazopyridines as angiotensin II antagonists Novel imidazopyridine derivatives of formula I ##STR1## wherein ##STR2## and R1, R2, R3, R4, X and Y are as defined herein, and their salts, exhibit antagonistic properties toward angiotensin II and ca... | 08/01/1995 |
| 5405964 | Imidazopyridines Novel imidazopyridine derivatives of formula I ##STR1## and X, --Y.dbd.Z--, R1, R2, R3, R4 and R5 as defined herein, and their salts, exhibit antagonistic properties towards angiotensin II and ca... | 04/11/1995 |
| 5401738 | Benzimidazole compounds Benzimidazole compounds of the formula I ##STR1## and salts thereof, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and an increased intraocular pressure, ... | 03/28/1995 |
| 5389642 | Imidazopyridines Novel imidazopyridine derivatives of the formula I ##STR1## in which R is ##STR2## and R1 to R4, X and Y are as defined herein, and their salts have antagonistic properties towards angiotensin(II) and can be used for t... | 02/14/1995 |
