Inventor: Igor Gonda

Address: San Francisco, CA
No. of patents: 34
Last patent issue date: 11/11/2008

Number	Title	Issue Date
7448375	Method of treating diabetes mellitus in a patient Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the patient each t...	11/11/2008
7278419	Method for treating diabetes mellitus in a patient The need for the delivery of insulin by injection can be reduced or eliminated by delivering aerosolized insulin. Repeatability of dosing is obtainable by using either regular insulin or monomeric insulin. When delivering insulin (not monomeric) by inhalation, the t...	10/09/2007
7244714	Methods of delivering aerosolized polynucleotides to the respiratory tract Methods and devices for delivering aerosolized formulations containing polynucleotides to specified regions within a subject's respiratory tract are disclosed. The methods find use in the delivery of ribozymes, antisense polynucleotides, and DNA and RNA expression v...	07/17/2007
7028686	Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the patient each t...	04/18/2006
7018825	DNase liquid solutions The present invention relates to the use of calcium ion and/or sugars to minimize thermal aggregation of DNase and to the use of calcium ion to stabilize liquid solutions of DNase, the solutions having a pH of less than neutral. DNase is the active pharmaceutical pr...	03/28/2006
6688304	Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the pat...	02/10/2004
6551542	Method of fabricating porous membrane with unique pore structure for aerosolized delivery of drugs A method for producing a nozzle useful in generating a fine aerosol for delivery of therapeutic or diagnostic agents is provided. The method comprises focusing a laser source onto a thin, preferably flexible material so as to form pores substantially thro...	04/22/2003
6543442	Aerosol-forming porous membrane with certain pore structure A nozzle comprised of a thin, flexible membrane material having a plurality of pores is disclosed. In one embodiment, the pores have an unflexed exit aperture diameter in the range of about 0.5 to about 2 microns (preferably about 1 micron) and are positi...	04/08/2003
6431167	Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin The need for the delivery of insulin by injection can be reduced or eliminated by delivering an aerosolized monomeric insulin formulation. Repeatability of dosing and more particularly the repeatability of the blood concentration versus time profile is im...	08/13/2002
6431166	Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin The need for the delivery of insulin by injection can be reduced or eliminated by delivering an aerosolized monomeric insulin formulation. Repeatability of dosing and more particularly the repeatability of the blood concentration versus time profile is im...	08/13/2002
6427681	Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin The need for the delivery of insulin by injection can be reduced or eliminated by delivering an aerosolized monomeric insulin formulation. Repeatability of dosing and more particularly the repeatability of the blood concentration versus time profile is im...	08/06/2002
6408854	Insulin delivery enhanced by coached breathing The need for the delivery of insulin by injection can be reduced or eliminated by a method whereby an aerosolized insulin formulation is delivered to a patient's lungs and the rate at which the insulin is absorbed into the blood is increased by the use of...	06/25/2002
6383788	Minimizing thermally induced aggregation of DNase in solution with calcium The present invention relates to the use of calcium ion and/or sugars to minimize thermal aggregation of DNase and to the use of calcium ion to stabilize liquid solutions of DNase, the solutions having a pH of less than neutral. DNase is the active pharma...	05/07/2002
6349719	Formulation and devices for monitoring the efficacy of the delivery of aerosols Aerosolizable formulations are disclosed comprised of a pharmaceutically acceptable carrier, a pharmaceutically active drug or detectably labeled compound and a compound which is recognized by its distinct color, taste and/or smell even when present in a ...	02/26/2002
6250298	Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin The need for the delivery of insulin by injection can be reduced or eliminated by delivering an aerosolized monomeric insulin formulation. Repeatability of dosing and more particularly the repeatability of the blood concentration versus time profile is im...	06/26/2001
6230706	Method and device for creating aerosol with porous membrane with certain pore structure A nozzle comprised of a thin, flexible membrane material having a plurality of pores is disclosed. In one embodiment, the pores have an unflexed exit aperture diameter in the range of about 0.5 to about 2 microns (preferably about 1 micron) and are positi...	05/15/2001
6227195	Coarse spray delivery of functional biologic material The present invention relates to a method of introducing biologic materials into the conducting airways of the bronchial system. The invention involves the use of a liquid carrier or suspension for the biologic materials, delivered in relatively large dro...	05/08/2001
6192882	Formulation and devices for monitoring the efficacy of the delivery of aerosols Aerosolizable formulations are disclosed comprised of a pharmaceutically acceptable carrier, a pharmaceutically active drug or detectably labeled compound and a compound which is recognized by its distinct color, taste and/or smell even when present in a ...	02/27/2001
6167880	Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the pat...	01/02/2001
6131567	Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin The need for the delivery of insulin by injection can be reduced or eliminated by delivering an aerosolized monomeric insulin formulation. Repeatability of dosing and more particularly the repeatability of the blood concentration versus time profile is im...	10/17/2000
6085753	Insulin delivery enhanced by coached breathing The need for the delivery of insulin by injection can be reduced or eliminated by a method whereby an aerosolized insulin formulation is delivered to a patient's lungs and the rate at which the insulin is absorbed into the blood is increased by the use of...	07/11/2000
6070575	Aerosol-forming porous membrane with certain pore structure A nozzle comprised of a thin, flexible membrane material having a plurality of pores is disclosed. In one embodiment, the pores have an unflexed exit aperture diameter in the range of about 0.5 to about 2 microns (preferably about 1 micron) and are positi...	06/06/2000
6024090	Method of treating a diabetic patient by aerosolized administration of insulin lispro The need for the delivery of insulin by injection can be reduced or eliminated by delivering an aerosolized monomeric insulin formulation. Repeatability of dosing and more particularly the repeatability of the blood concentration versus time profile is im...	02/15/2000
5970973	Method of delivering insulin lispro The need for the delivery of insulin by injection can be reduced or eliminated by a method whereby an aerosolized insulin formulation is delivered to a patient's lungs and the rate at which the insulin is absorbed into the blood is increased by the use of...	10/26/1999
5941240	Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the pat...	08/24/1999
5906202	Device and method for directing aerosolized mist to a specific area of the respiratory tract Methodology and devices for delivering aerosolized formulation to target areas of a patient's respiratory tract are disclosed. The device is a hand-held, self-contained unit which is readily portable and capable of measuring a variety of parameters includ...	05/25/1999
5888477	Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin The need for the delivery of insulin by injection can be reduced or eliminated by a method whereby an aerosolized insulin formulation is delivered to a patient's lungs and the rate at which the insulin is absorbed into the blood is increased by the use of...	03/30/1999
5884620	Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the pat...	03/23/1999
5873358	Method of maintaining a diabetic patient's blood glucose level in a desired range The need for the delivery of insulin by injection can be reduced or eliminated by a method whereby an aerosolized insulin formulation is delivered to a patient's lungs and the rate at which the insulin is absorbed into the blood is increased by the use of...	02/23/1999
5829435	Prefilter for prevention of clogging of a nozzle in the generation of an aerosol and prevention of administration of undesirable particles A device, drug package and methodology for using such to generate an aerosol by moving a flowable formulation through a low resistance filter and then through a nozzle comprised of a porous membrane are disclosed. The package is comprised of a collapsible...	11/03/1998
5770152	Collapsible container for measuring particles in a sample fluid A device and method for the detection of small particles in a fluid. The device is a collapsible sample container having a opening which is covered, at least in part, by a porous membrane having a plurality (e.g., 100) of pores therein having a pore diame...	06/23/1998
5743250	Insulin delivery enhanced by coached breathing The need for the delivery of insulin by injection can be reduced or eliminated by a method whereby an aerosolized insulin formulation is delivered to a patient's lungs and the rate at which the insulin is absorbed into the blood is increased by the use of...	04/28/1998
5641510	Method for treating capsules used for drug storage Capsules (such as hard gelatin, cellulose and plastic capsules) containing pharmaceutical powders which are administered to a patient via inhalation are treated so as to increase the effective amount of the pharmaceutical agent reaching the respiratory sy...	06/24/1997
5457044	Method for collection of aerosolized proteins by inert filtration A method for collecting an aerosolized therapeutic polypeptide of interest, such as recombinant human deoxyribonuclease I (rhDNase), is provided which enables a determination as to the effect aerosolization has on the activity and integrity of the polypep...	10/10/1995

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Inventor: Igor Gonda