Inventor: Geoffrey Lawton

Address: Hitchin, GB2
No. of patents: 21
Last patent issue date: 02/24/1998

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Number	Title	Issue Date
5721245	4-3-indolyl!-1H-pyrrolone A compound of the formula ##STR1## wherein R is hydrogen or hydroxy, R1 and R2 taken together are a group of the formula --(CH2)m -- and R7 is hydrogen or R1 and R7 taken to...	02/24/1998
5721230	Substituted pyrroles Compounds of the formula ##STR1## wherein R1 is lower alkyl, lower cycloalkyl, aryl or lower aralkyl; R2 is hydrogen, aryl or lower alkyl optionally substituted by hydroxy, acyloxy, amino, mono(lower alkyl)amino, di(lower alkyl)...	02/24/1998
5447929	Method of treating joint disorders using hydroxamic derivatives Hydroxamic acid derivatives of the fdrrnula ##STR1## and pharmaceutically acceptable salts thereof, which are collagenase inhibitors useful for the control or prevention of degenerative joint diseases, such as, rheumatoid arthritis and ostecarthritis...	09/05/1995
5318964	Hydroxamic derivatives and pharmaceutical compositions Hydroxamic acid derivatives of the formula ##STR1## and pharmaceutically acceptable salts thereof, which are collagenase inhibitors useful for the control or prevention of degenerative joint diseases, such as, rheumatoid arthritis and osteoarthritis ...	06/07/1994
5304549	Amino acid derivatives Compounds of the formula ##STR1## wherein A is the group ##STR2## R1 is hydrogen, amino, protected amino, acylamino or lower alkyl optionally substituted by aryl, hydroxy, protected hydroxy, amino, protected amino, acylamino, mal...	04/19/1994
5114960	Substituted isoxazole derivatives Compounds of the formula ##STR1## wherein A taken together with the two carbon atoms denoted as ଱ and ଲ is a group of the formula ##STR2## and the dotted line is the double bond present in formulas (i) and (iii); and wherein n i...	05/19/1992
5057614	Substituted pyrroles Compounds of the formula ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, X and Y have the signficance given in the description, are useful in the control or prevention of infla...	10/15/1991
5006651	Phosphinic acid derivatives The invention relates compounds of the formula ##STR1## wherein R1 -R5 and X have the significance given in the description, and their pharmaceutically acceptable salts. The compounds of formula I inhibit the enzyme collagenase ...	04/09/1991
4920119	Triazine derivatives Compounds of the formula ##STR1## wherein A represents a grouping of the formula ##STR2## in which R1 and R2 each individually represent hydrogen, halogen, trifluoromethyl, nitro, amino, cyano, C1 -C6 ...	04/24/1990
4885283	Phosphinic acid derivatives The invention relates compounds of the formula ##STR1## wherein R1 -R5 and X have the significance given in the description, and their pharmaceutically acceptable salts. The compounds of formula I inhibit the enzyme collagenase ...	12/05/1989
4826980	Pyridazine intermediates Compounds of the formula ##STR1## wherein R1 is hydrogen, alkanoyl or aroyl; R2 is hydrogen or alkyl; R3 is hydrogen or aryl; R4 and R5 each are hydrogen or R4 and R5 taken ...	05/02/1989
4785093	Bicyclic compounds Compounds of the formula ##STR1## wherein R1 is hydrogen, alkanoyl or aroyl; R2 is hydrogen or alkyl; R3 is hydrogen or aryl; R4 and R5 each are hydrogen or R4 and R5 taken ...	11/15/1988
4782149	Pyridazodiazepine derivatives Compounds of the formula ##STR1## wherein R1 and R2 each independently represent hydrogen, C1 -C10 -alkyl, adamantyl-(C1 -C4 -alkyl) or (C2 -C6 -alkanoyloxy)-(C	11/01/1988
4772701	Pyridazo[1,2]pyridazines and pyrazolo[1,2]pyridazines as antihypertensives Novel compounds of the formula ##STR1## wherein B represents a methylene, ethylene or vinylene group, R1 represents a hydrogen atom or an alkyl, aralkyl, amino-alkyl, mono-alkylamino-alkyl, dialkylamino-alkyl, acylamino-alkyl, phthali...	09/20/1988
4762924	Bicyclic compounds Compounds of the formula ##STR1## wherein R1 is hydrogen, alkanoyl or aroyl; R2 is hydrogen or alkyl; R3 is hydrogen or aryl; R4 and R5 each are hydrogen or R4 and R5 taken ...	08/09/1988
4757069	Pyridazodiazepine derivatives Compounds of the formula ##STR1## wherein R1 and R2 each independently represent hydrogen, C1 -C10 -alkyl, adamantyl-(C1 -C4 -alkyl) or (C2 -C6 -alkanoyloxy)-(C	07/12/1988
4743687	Pyridazo (1,2-a) (1,2) diazepine derivatives Compounds of the formula ##STR1## wherein R1 represents hydroxy, alkyl, aralkyl, aralkoxy-alkyl, hydroxy-alkyl, amino-alkyl, acylamino-alkyl, monoalkylamino-alkyl, dialkylamino-alkyl, alkoxycarbonylamino-alkyl, halo-alkyl, carboxy-alkyl, ...	05/10/1988
4692438	Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity Compounds of the formula ##STR1## wherein R1 is hydrogen, alkanoyl or aroyl; R2 is hydrogen or alkyl; R3 is hydrogen or aryl; R4 and R5 each are hydrogen or R4 and R5 taken ...	09/08/1987
4512924	Pyridazo[1,2-a][1,2]diazepines Novel compounds of the formula ##STR1## wherein B represents a methylene, ethylene or vinylene group, R1 represents a hydrogen atom or an alkyl, aralkyl, amino-alkyl, mono-alkylamino-alkyl, dialkylaminoalkyl, acylamino-alkyl, phthalim...	04/23/1985
4487929	Intermediates for pyrazolopyridazine derivatives Intermediates of the formula ##STR1## wherein A is methylene, ethylene or propylene which may be substituted by lower alkyl, Y is halogen, R3 is hydrogen, lower alkyl, aryl or aryl-(lower alkyl)--, R20 l is lower alkoxy and R	12/11/1984
4399136	Pyrazolopyridazine antihypertensives Compounds of the formula ##STR1## wherein A is methylene, ethylene or propylene which may be substituted by lower alkyl, B is carbonyl or methylene, R1 is halogen, carboxyl, lower alkoxycarbonyl, hydroxyaminocarbonyl, mercapto, lower alkan...	08/16/1983

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Inventor: Geoffrey Lawton