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Pneumatic Shoe Lacing Apparatus
This invention provides a pneumatic shoe lacing apparatus for the pneumatic lacing of shoe.
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| Number | Title | Issue Date |
| 7638629 | Piperidines and related compounds for treatment of alzheimer's disease Compounds of formula I: selectively inhibit production of Aβ(1-42) and hence are useful in treatment or prevention of disease associated with deposition of β-amyloid in the brain. ... | 12/29/2009 |
| 7101892 | Sulfone derivatives as 5-HT7 receptor ligands The present invention relates to sulfone derivatives of formula (I): Ar—SO2—CR2R3-L-N(R1)2I wherein Ar, L, R1, R2 and R3 are as defined herein, and pharma... | 09/05/2006 |
| 6489343 | Tetrahydropyran derivatives and their use as therapeutic agents The present invention relates to compounds of the formula (I): ##STR1## wherein R1 is fluorine or trifluoromethyl; R2 is fluorine or trifluoromethyl; R3 is methyl or hydroxymethyl; R4 represents a variety of substituents;... | 12/03/2002 |
| 6271230 | Use of NK-1 receptor antagonists for treating cognitive disorders The present invention provides methods for the treatment or prevention of cognitive disorders which comprises oral administration of an orally active, long acting, CNS-penetrant NK-1 receptor antagonist and pharmaceutical compositions comprising such a NK... | 08/07/2001 |
| 6172077 | Spiro-azacyclic derivatives and their use as therapeutic agents The present invention is directed to substituted spiro-azacyclic derivatives of the formula (I): ##STR1## (wherein R1, R2, R3, R4, R5, R6, R9, R10, X, Y, p and q are d... | 01/09/2001 |
| 6114315 | Use of NK-1 receptor antagonists for treating major depressive disorders with anxiety The present invention provides methods for the treatment or prevention of major depressive disorder with anxiety without concomitant therapy with other anti-depressant or anti-anxiety agents which comprises oral administration of an orally active, long ac... | 09/05/2000 |
| 6096729 | Use of NK-1 receptor antagonists for treating amnestic disorders The present invention provides methods for the treatment or prevention of amnestic disorders which comprises oral administration of an orally active, long acting, CNS-penetrant NK-1 receptor antagonist.... | 08/01/2000 |
| 6087348 | Use of NK-1 receptor antagonists for treating stress disorders The present invention provides the use of an orally active, long acting, CNS-penetrant NK-1 receptor antagonist for the manufacture of a medicament adapted for oral administration for the treatment or prevention of stress disorders without concomitant the... | 07/11/2000 |
| 6071927 | Spiro-piperidine derivatives and their use as therapeutic agents The present invention relates to certain spiro-piperdine derivatives which are tachykinnin antagonists and are useful, for example, in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia.... | 06/06/2000 |
| 6046195 | Spiro-azacyclic derivatives, their preparation and their use as tachykinin antagonists The present invention relates to certain spiro-azacyclic derivatives which are tachykinin antagonists and are useful, for example, in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia.... | 04/04/2000 |
| 5952315 | Use of NK-1 receptor antagonists for treating bipolar disorders The present invention provides methods for the treatment or prevention of bipolar disorder without concomitant therapy with other antidepressant or anti-anxiety agents which comprises oral administration of an orally active, long acting, CNS-penetrant NK-... | 09/14/1999 |
| 5929054 | Use of NK-1 receptor antagonists for treating sexual dysfunctions The present invention provides a method for the treatment or prevention of sexual dysfunctions which comprises oral administration of an orally active, long acting, CNS-penetrant NK-1 receptor antagonist and pharmaceutical compositions comprising such an ... | 07/27/1999 |
| 5925627 | Use of NK-1 receptor antagonists for treating movement disorders The present invention provides a method for the treatment or prevention of movement disorders using an orally active, long acting, CNS-penetrant NK-1 antagonist and pharmaceutical compositions comprising such an antagonist.... | 07/20/1999 |
| 5919781 | Use of NK-1 receptor antogonists for treating substance use disorders The present invention provides a method for the treatment or prevention of substance use disorders using an orally active, long acting, CNS-penetrant NK-1 receptor antagonist and pharmaceutical compositions comprising such a NK-1 receptor antagonist.... | 07/06/1999 |
| 5877316 | Morpholine derivatives, compositions containing them and their use as therapeutic agents The present invention relates to compounds of formula (I), wherein R1 and R4 represent hydrogen, halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C3-7 cycloalkyl... | 03/02/1999 |
| 5747491 | Morpholine derivatives and their use as antagonists of tachikinins The present invention relates to compounds of formula (I): wherein X is N or CH; and pharmaceutically acceptable salts and prodrugs thereof. The compounds are of p articular use in the treatment of pain, inflammation, migraine and emesis. ##STR1##... | 05/05/1998 |
| 5665883 | Aralkoxy and aralkylthio substituted azacyclic compounds as tachykinin antagonists The present invention relates to compounds of formula (I) wherein n is 3 and where any carbon atom of (CH2)n may be substituted by R4 and/or R5 ; X represents O or S; R1 represents (CH2) | 09/09/1997 |
