Inventor: Donald G. Wallace

Address: Menlo Park, CA
No. of patents: 30
Last patent issue date: 12/21/2004

Number	Title	Issue Date
6833408	Methods for tissue repair using adhesive materials A method of tissue repair is provided using a biocompatible nonimmunogenic adhesive composition. The adhesive composition comprises collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so...	12/21/2004
6653450	Mutated recombinant collagens The invention provides recombinant procollagen chains having a natural collagen chain separated from one or two propeptides by one or two non-natural site-specific proteolytic agent (e.g., protease) recognition sites. A wide variety of propeptides and sit...	11/25/2003
6624245	Rapid-gelling biocompatible polymer composition and associated methods of preparation and use A method is provided for the rapid formation of a biocompatible gel, and may be carried out in situ, i.e., at a selected site within a patient's body. The method involves admixing a biocompatible crosslinking component A having m sulfhydryl groups wherein...	09/23/2003
6495127	Compositions and systems for forming high strength medical sealants, and associated methods of preparation and use The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally activated synthetic polymers, along with a tensile strength e...	12/17/2002
6458889	Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use Crosslinkable compositions are provided that readily crosslink in situ to provide biocompatible, nonimmunogenic crosslinked biomaterials. The compositions contain at least three biocompatible, nonimmunogenic components having reactive functional groups th...	10/01/2002
6413737	Ecarin prothrombin protease and methods New forms of ecarin, a procoagulant protein from Echis carinatus venom, are described, as are polynucleotides encoding the new proteins, methods for production of the new proteins, and methods for activation of prothrombin using the new proteins. The new ...	07/02/2002
6312725	Rapid gelling biocompatible polymer composition This invention relates generally to two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue...	11/06/2001
6280727	Compositions containing thrombin and microfibrillar collagen and methods for preparation and use thereof The present invention relates to thrombin-containing hemostatic compositions, their preparation and use. In particular, it relates to hemostatic compositions comprising stabilized thrombin and microfibrillar collagen in an aqueous medium. In a preferred e...	08/28/2001
6096309	Compositions containing thrombin and microfibrillar nanometer collagen, and methods for preparation and use thereof The present invention relates to thrombin-containing hemostatic compositions, their preparation and use. In particular, it relates to hemostatic compositions comprising stabilized thrombin and microfibrillar collagen in an aqueous medium. In a preferred e...	08/01/2000
6066325	Fragmented polymeric compositions and methods for their use Cross-linked hydrogels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such hydrogels preferably have no free aqueous phase and may be applied to target sites in a patient's body by extr...	05/23/2000
6063061	Fragmented polymeric compositions and methods for their use Molecular cross-linked gels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such molecular gels may be applied to target sites in a patient's body by extruding the gel through an orifice...	05/16/2000
5931165	Films having improved characteristics and methods for their preparation and use Gelatin film compositions are useful for immobilization over tissue, usually by the application of energy to the films. Exemplary films comprise cross-linked and non-cross-linked granular and non-granular gelatin sheets, typically including a plasticizer....	08/03/1999
5749895	Method for bonding or fusion of biological tissue and material Biological materials are joined, repaired or fused by heating the material in proximity to a mechanical support. Preferably, the mechanical support comprises a patch or bridge structure. In the most preferred embodiment, the patch is formed from collagen ...	05/12/1998
5550188	Polymer conjugates ophthalmic devices comprising collagen-polymer conjugates Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The ate...	08/27/1996
5543441	Implants coated with collagen-polymer conjugates Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer....	08/06/1996
5523348	Method of preparing collagen-polymer conjugates Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer....	06/04/1996
5446091	Collagen-polymer conjugates containing an ether linkage Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The ate...	08/29/1995
5413791	Collagen-polymer conjugates Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The ate...	05/09/1995
5376375	Method of augmenting tissue using collagen-polymer conjugates Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer....	12/27/1994
5352715	Injectable ceramic compositions and methods for their preparation and use Injectable implant compositions comprise a biocompatible ceramic matrix present in a fluid carrier, where the ceramic matrix comprises particles having a size distribution in the range from 50 μm to 250 μm. Optionally, the compositions may further compr...	10/04/1994
5328955	Collagen-polymer conjugates Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The ate...	07/12/1994
5324775	Biologically inert, biocompatible-polymer conjugates Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding biologically inactive, natural, biocompatible polymer to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide bioc...	06/28/1994
5304595	Collagen-polymer conjugates Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer....	04/19/1994
5264214	Composition for bone repair Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer....	11/23/1993
5204382	Injectable ceramic compositions and methods for their preparation and use Injectable implant compositions comprise a biocompatible ceramic matrix present in a fluid carrier, where the ceramic matrix comprises particles having a size distribution in the range from 50 μm to 250 μm. Optionally, the compositions may further compr...	04/20/1993
5162430	Collagen-polymer conjugates Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer....	11/10/1992
4803075	Injectable implant composition having improved intrudability Injectable aqueous suspensions of biomaterials, such as cross-linked collagen, that contain a biocompatible fluid lubricant, such as glycogen or maltose, are disclosed. The inclusion of the lubricant significantly improves the intrusion of the suspension ...	02/07/1989
4789663	Methods of bone repair using collagen A method of repairing bone defects by use of suspensions containing purified atelopeptide, reconstituted, fibrillar skin collagen or bone collagen powder or mixtures thereof is disclosed. The suspensions provide matrices for conductive growth of bone into...	12/06/1988
4582640	Injectable cross-linked collagen implant material Cross-linked atelopeptide collagen that is substantially free of residual cross-linking agent is prepared by: reconstituting atelopeptide collagen from solution by neutralizing the solution at a reduced temperature and a hypotonic ionic strength; cross-li...	04/15/1986
4424208	Collagen implant material and method for augmenting soft tissue An injectable implant material for soft tissue augmentation comprising a dispersion of (a) particles of cross-linked atelopeptide collagen; and (b) reconstituted fibrous atelopeptide collagen in a (c) physiological aqueous carrier. Implants of this materi...	01/03/1984

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