Inventor: Dennis Bigg

Address: Gif-sur-Yvette, FR
No. of patents: 32
Last patent issue date: 06/07/2011

Number	Title	Issue Date
7956075	Derivatives of heterocycles with 5 members, their preparation and their use as medicaments The invention relates to thiazole, oxazole, imidazole, isoxazole and isoxazoline derivatives of general formula (I) wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is no...	06/07/2011
7534805	Imidazole derivatives, their preparation and their use as medicaments Novel imidazole compounds of the formula wherein the substituents are as defined in the application having antitumoral activity and use thereof. ...	05/19/2009
7402602	Imidazole derivatives modulating the sodium channels A method of treating cardiac rhythm disorders linked with neurodegenerating depression, bipolar disorders and irritable bowel disorders in warm-blooded animals in need thereof by administering a compound of the formula wher...	07/22/2008
7291641	Derivatives of heterocycles with 5 members, their preparation and their use as medicaments Thiaxozle, oxazole, imidazole, isoxazole and isoxazoline compounds of the formula wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is selected from the various...	11/06/2007
7192975	Arylimidazole derivatives, preparation and therapeutic used thereof Compounds of the formula wherein the substituents are as defined in the specification which are useful for the treatment of pain. ...	03/20/2007
7186752	Derivatives of N-(iminomethyl)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them N-(imino)amines and their preparation and their use as NO synthase inhibitors and selective or non-selective traps for a reactive oxygen species. ...	03/06/2007
7157483	Imidazole derivatives modulating the sodium channels A method of modulating, sodium channels in warm-blooded animals in need thereof by administering a compound of the formula Wherein the substituents are defined as in the specification and compounds of the formula...	01/02/2007
7053102	Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them Compositions for treating cancer comprising an amount of a camptothecin with a 7-ring β-hydroxy lactone ring of the formula wherein the substituents are defined as in the specification sufficient to treat cancer...	05/30/2006
7015213	Use of diazepines for preparing medicines for treating pathological conditions or diseases involving one of the growth hormone release inhibiting factor receptors The invention concerns the use of pyrido-thieno-triazolo-diazepins for preparing a medicine for treating pathological conditions or diseases involving one of the growth hormone release inhibiting factor receptors. The invention also concerns novel pyrido-thieno-tria...	03/21/2006
7012079	Optically pure camptothecin analogues The invention relates in particular to the compounds of general formula in which R1, R2, R3, R4, R5, R6 represent various radicals; their use as medicame...	03/14/2006
6797715	Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them A method of treating a cancer in warm-blooded animals by administration to the warm-blooded animals in need thereof a camptothecin analog a 7-ring member β-hydroxy lactone ring of the formula wherein the substituents ar...	09/28/2004
6777408	Pyrido-thieno-diazepines method for the production thereof and pharmaceutical compositions containing said pyrido-thieno-diazepines The present invention relates to novel pyrido-thieno-diazepines, their preparation process and the pharmaceutical compositions containing them. These diazepines are particularly useful for treating pathological states or diseases in which one (or more) somatostatin ...	08/17/2004
6762301	Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them A process for the preparation of a compound of the formula wherein the substituents are defined as set forth in the specification comprising reacting a compound of the formula	07/13/2004
6727239	Derivatives of 2-aminopyridines, their use as medicaments and pharmaceutical compositions containing them A compound of the formula wherein the substituents are defined as in the specification and their pharmaceutically acceptable salts having NOS and ROS activity. ...	04/27/2004
6670400	Phenoxyethylamine derivatives having high affinity for the 5-HT1A receptor, preparation thereof, use thereof as drugs, and pharmaceutical compositions containing said derivatives Phenoxyethylamine derivatives of general formula (I) having high affinity for the 5-HT1A receptor, methods for preparing same, pharmaceutical compositions containing said derivatives, and their use, in particular as gastric acid secretion inhib...	12/30/2003
6632946	Tetracyclic analogues of camptothecins, their preparation processes, their use as medicaments and the pharmaceutical compositions containing them The invention relates to new tetracyclic analogues of camptothecin, their preparation processes, their use as medicaments and the pharmaceutical compositions containing them. Said analogues, which include in particular 3-hydroxy-3-(4-oxo-4,6-dihydroindoli...	10/14/2003
6630461	Derivatives of 2-(iminomethyl) amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them A method for treating neurodegenerative diseases in a warm-blooded animal comprising administering to a warm-blooded animal in need thereof an amount of a compound of the formula ##STR1## wherein A selected from the group consisting of hydrogen and #...	10/07/2003
6620840	Derivatives of N-(iminomethyl)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them N-(imino)amines and their preparation and their use as NO synthase inhibitors and selective or non-selective traps for a reactive oxygen species....	09/16/2003
6599903	Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them Intermediate compounds having the formula ##STR1## wherein the substituents are defined as set forth in the disclosure....	07/29/2003
6586454	Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them A compound of the formula XXV(H) wherein the substituents are defined as set forth in the specification which are useful intermediates for the production of derivatives of 2-(iminomethyl)-amino-phenyl having inhibitory activity on NO-synthase enzymes....	07/01/2003
6482822	N-(iminomethyl)amines derivatives, their preparation, their use as medicines and compositions containing them The invention concerns novel N-(iminomethyl)amine derivatives comprising in their skeleton the aminophenylamine, oxodiphenylamine, carbazole, phenazine, phenoxazine or oxodiphenyl motif, their use as medicines and pharmaceutical compositions containing th...	11/19/2002
6436951	Camptothecin tetracyclic analogues, preparation, method, applications as medicines and pharmaceutical compositions containing them The invention relates to new tetracyclic analogues of camptothecin, their preparation processes, their use as medicaments and the pharmaceutical compositions containing them. Said analogues, which include in particular 3-hydroxy-3-(4-oxo-4,6-dihydroindoli...	08/20/2002
6340700	2-(iminomethyl) amino-phenyl derivatives, preparation, application as medicines and pharmaceutical compositions containing same A compound of the formula ##STR1## wherein the substituents are defined as in the specification and their pharmaceutically acceptable salts having NOS and ROS activity....	01/22/2002
6339091	Comptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues The compound of the formula ##STR1## wherein the substituents are defined as in the specification and its non-toxic, pharmaceutically acceptable salts which are useful for the treatment of viral infections, parasitic diseases and the treatment of can...	01/15/2002
6335445	Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them A compound selected from the group consisting of a compound of the formula ##STR1## wherein A is selected from the group consisting of ##STR2## and the other substituents are defined in the specification having an inhibitory activity of NO-synthase enzyme...	01/01/2002
6313135	Analogues of camptothecin, preparation procedures, their application as medicines and the pharmaceutical compositions comprising them A compound of the formula ##STR1## wherein the substituents are as defined in the specification and a method of inhibiting tumors....	11/06/2001
6300499	댑-adrenergic receptor antagonists Phenylpiperazine derivatives having high affinity for the 댑 -adrenoreceptor and pharmaceutical compositions containing them. Also disclosed is a method of using the such derivatives to treat benign prostatic hyperplasia....	10/09/2001
6297281	Association of no syntase inhibitors with trappers of oxygen reactive forms The invention concerns a pharmaceutical composition containing, as active principle, at least one NO syntase inhibiting substance and at least one oxygen reactive form trapping substance, optionally with a pharmaceutically acceptable support. The inventio...	10/02/2001
6222032	Use of ylides of phosphorus as slightly nuceophilic strong bases In a process for C-alkylation or N-alkylation, the improvement comprising conducting the C-alkylation or N-alkylation reaction in the presence of a slightly nucleophilic strong base of the following formula ##STR1## wherein R'1, R'2 ...	04/24/2001
6150417	Phenoxyethylamine derivatives, method of preparation application as medicine and pharmaceutical compositions containing same Novel method for treating warm-blooded animals for inducing anti-emetic activity, accelerating gastric emptying, modifying intestinal transit and anxiety, depression and sleep disorders by administration of a compound of the formula ##STR1## whe...	11/21/2000
6063784	Heteroaryloxyethylamines, method of preparation, application as medicine and pharmaceutical compositions containing them A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as in the application and its non-toxic, pharmaceutically acceptable acid addition salts which are useful for treating hypertensi...	05/16/2000
5981542	Camptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues A camptothecin analog characterized in that the hydroxy lactone of the camptothecin is a ଲ-hydroxy lactone or the corresponding ଲ-hydroxyacid, resulting from the opening of said lactone, or a derivative of said ଲ-hydroxyacid, or a Pharma...	11/09/1999

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Inventor: Dennis Bigg