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| Number | Title | Issue Date |
| 7338807 | Screening assays for compounds that cause apoptosis This invention relates to methods of screening for compounds capable of inducing apoptosis in certain tumor cells. The invention also relates to compounds identified by such methods. In addition, the invention relates to methods for the in vitro diagnosis of Xero... | 03/04/2008 |
| 6613883 | Screening assays for compounds that cause apoptosis and related compounds This invention relates to methods of screening for compounds capable of inducing apoptosis in certain tumor cells. The invention also relates to compounds identified by such methods. In addition, the invention relates to methods for the in vitro diagnosis... | 09/02/2003 |
| 6602979 | Screening assays for compounds that cause apoptosis This invention relates to methods of screening for compounds capable of inducing apoptosis in certain tumor cells. The invention also relates to compounds identified by such methods. In addition, the invention relates to methods for the in vitro diagnosis... | 08/05/2003 |
| 5985829 | Screening assays for compounds that cause apoptosis and related compounds This invention relates to methods of screening for compounds capable of inducing apoptosis in certain tumor cells. The invention also relates to compounds identified by such methods. In addition, the invention relates to methods for the in vitro diagnosis... | 11/16/1999 |
| 5759765 | Human liver epithelial cell lines Immortalized cell lines derived from normal adult human liver are described which express phenotypic characteristics of normal adult liver epithelial cells. The invention further provides methods of using the immortalized cells to evaluate the cytotoxicit... | 06/02/1998 |
| 5665589 | Human liver epithelial cell lines Immortalized cell lines derived from normal adult human liver are described which express phenotypic characteristics of normal adult liver epithelial cells.... | 09/09/1997 |
| 5604118 | Eukaryotic expression vector system The present invention relates to two plasmid vectors and eucaryotic expression vector created therefrom. The present invention further relates to a method of cloning a gene in a eucaryotic cell the expression of which is affected by drug treatment, a meth... | 02/18/1997 |
| 5529920 | Human liver epithelial cell line and culture media therefor The present invention relates to long term multiplication and permanent establishment of a cell line of human liver epithelial cells(hepatocytes). The human liver epithelial cell line is capable of mitotically proliferating and continuously growing in vit... | 06/25/1996 |
| 5506131 | Immortalized human cell lines containing exogenous cytochrome P450 genes Non-tumorigenic, stable, human bronchial and liver epithelial cell lines are provided wherein the cell lines are capable of expressing human cytochrome P450 genes which have been inserted into the cell lines. Also provided are methods and kits for identif... | 04/09/1996 |
| 5443954 | Immortalized non-tumorigenic human bronchial epithelial cell lines Immortalized human bronchial epithelial and human mesothelial cell lines have been obtained. Various uses of these cell lines have been described.... | 08/22/1995 |
| 5432060 | Immortalized human bronchial epithelial cell line Human bronchial epithelial cell lines permanently transformed by human papilloma viruses have been obtained. These cell lines are useful for the study of growth and differentiation in bronchial carcinoma and the identification of chemical and biological a... | 07/11/1995 |
| 5356806 | Immortalized human cell lines containing exogenous cytochrome P450 Non-tumorigenic, human bronchial epithelial cell lines are provided wherein the cell lines are capable of expressing cytochrome P450 genes which have been inserted into the cell lines. Also provided are methods and kits for identifying potential mutagens,... | 10/18/1994 |
| 5342777 | Cell culture medium for human liver epithelial cell line The present invention relates to cell medium developed to support long term multiplication and permanent establishment of a cell line of human liver epithelial cells. The medium may contain an effective cell growth promoting amount of calcium ions; an eff... | 08/30/1994 |
| 5096808 | Method and kit for detecting human exposure to genotoxic agents The present invention discloses a method and a kit for monitoring human exposure to genotoxic agents. The method comprises an immunoassay for detecting in human serum specific antibodies against DNA adducted to an agent suspected of being genotoxic. A kit... | 03/17/1992 |
| 4885238 | Immortalized human bronchial epitherial mesothelial cell lines Immortalized human bronchial epithelial and human mesothelial cell lines have been obtained. Various uses of these cell lines have been described.... | 12/05/1989 |
| 4794074 | Method and kit for detecting human exposure to genotoxic agents The present invention discloses a method and a kit for monitoring human exposure to genotoxic agents. The method comprises an immunoassay for detecting in human serum specific antibodies against DNA adducted to an agent suspected of being genotoxic. A kit... | 12/27/1988 |
| 4608339 | Protoplast fusion method for high-frequency DNA transfection in human cells A modified protoplast fusion method and cell line is disclosed that stably transfects human cells with pSV2-derived plasmids at frequencies greater than 10-3. This procedure makes it possible to test the biological effect of individual genes (i... | 08/26/1986 |
| 4463090 | Cascade amplification enzyme immunoassay The invention provides enzyme immunoassays whose sensitivity is increased by cascade amplification. The coupled ligand (enzyme or an activator) catalytically activates a second enzyme which acts on a substrate or can act on a third enzyme to produce a cas... | 07/31/1984 |
| 4289748 | Ultrasensitive enzymatic radioimmunoassay method A method of quantitatively measuring antigen or antibody concentration by selectively coupling an antigen to a solid substrate, coupling an enzyme-conjugated antibody to the antigen and reacting a radioindicator with the enzyme-conjugate producing a radio... | 09/15/1981 |
