Inventor: Chi-Huey Wong

Address: Rancho Santa Fe, CA
No. of patents: 53
Last patent issue date: 09/25/2012

Number	Title	Issue Date
8273788	Five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis therapeutics Novel 5-membered iminocyclitol derivatives were found to be a potent and selective inhibitors of the glycoprotein processing α- and β-glucosidase which were further found to be active antiviral agents against Japanese encephalitis virus, dengue virus serotype 2 (D...	09/25/2012
8163290	Glycolipids and analogues thereof as antigens for NKT cells This invention relates to immunogenic compounds which serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses. ...	04/24/2012
7998482	Methods and reagents for the analysis and purification of polysaccharides The disclosure provides fusion proteins comprising a carbohydrate recognition domain of an innate immunity receptor and a heterologous polypeptide. The fusion proteins of the disclosure may be used, for example, to fingerprint polysaccharide compositions and to puri...	08/16/2011
7923013	Glycolipids and analogues thereof as antigens for NKT cells This invention relates to immunogenic compounds which serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses. ...	04/12/2011
7919521	Five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis therapeutics Novel 5-membered iminocyclitol derivatives were found to be a potent and selective inhibitors of the glycoprotein processing α- and β-glucosidase which were further found to be active antiviral agents against Japanese encephalitis virus, dengue virus serotype 2 (D...	04/05/2011
7687064	Methods and compositions associated with administration of an extract of The present disclosure provides methods for increasing the lipopolysaccharide-induced secretion of IL-1 by macrophages, for increasing serum levels of IL-1 in a mammal, for increasing the serum level of IL-1 receptor antagonist (IL-1Ra) in a mammal, for increasing t...	03/30/2010
7534434	Glycolipids and analogues thereof as antigens for NK T cells This invention relates to immunogenic compounds which may serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses. ...	05/19/2009
7335500	Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose This invention contemplates improved methods of enzymatic production of carbohydrates especially fucosylated carbohydrates. Improved syntheses of glycosyl 1- or 2-phosphates using both chemical and enzymatic means are also contemplated. The phosphorylated glycosides...	02/26/2008
7323176	Immuno-modulating antitumor activities of ganoderma lucidum (reishi) polysaccharides The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of components of Ganoderma lucidum. These active extracts and fractions are useful for inh...	01/29/2008
7135578	Iminocyclitol inhibitors of hexoaminidase and glycosidase Designed imminocyclitols have potent inhibition activity with respect to hexoaminidases and glycosidases. ...	11/14/2006
7135183	Immuno-modulating antitumor activities of (Reishi) polysaccharides The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of plant components of Ganoderma lucidum. These active extracts and fractions are useful f...	11/14/2006
7019131	Programmable one-pot oligosaccharide synthesis The reactivity of a number of p-methylphenyl thioglycoside (STol) donors which are either fully protected or have one hydroxyl group exposed has been quantitatively determined by HPLC in conjunction with the development of a broadly applicable approach for a facile ...	03/28/2006
7018824	Mannosyl transfer with regeneration of GDP-mannose A one-pot glycosylation reaction is disclosed in which a mannosyl (Man) group is enzymatically transferred to an acceptor molecule. The starting glycoside is a mannosyl 1-phosphate that is enzymatically converted to its GDP derivative via UTP and a pyrophorylase. Th...	03/28/2006
6921810	Bifunctional antibiotics Bifunctional antibiotics that target both bacterial RNA and resistance-causing enzymes are disclosed. The A-site of bacterial 16S rRNA serves as the target site for most aminoglycoside antibiotics. Resistance to this class of antibiotics is frequently developed by m...	07/26/2005
6919440	Mannosyl transfer with regeneration of GDP-mannose A one-pot glycosylation reaction is disclosed in which a mannosyl (Man) group is enzymatically transferred to an acceptor molecule. The starting glycoside is a mannosyl 1-phosphate that is enzymatically converted to its GDP derivative via UTP and a pyrophorylase. Th...	07/19/2005
6900238	HIV protease inhibitors Combinatorial libraries of HIV and FIV protease inhibitors are characterized by α-keto amide or hydroxyethylamine core structures flanked by on one side by substituted pyrrolidines, piperidines, or azasugars and on the other side by phenylalanine, tyrosine, or subs...	05/31/2005
6803466	HIV/FIV protease inhibitors having a small P3 residue With the help of X-ray structural analyses of drug-resistant HIV proteases and molecular modeling, a new type of inhibitor with a small P3 residue has been developed. These inhibitors are effective against HIV and its drug-resistant mutants, as well as FIV. Modifica...	10/12/2004
6774140	Iminocyclitol inhibitors of hexoaminidase and glycosidase Designed iminocylitols that have potent inhibition activity with respect to hexominidases and glycosides are disclosed. ...	08/10/2004
6538117	Programmable one-pot oligosaccharide synthesis The reactivity of a number of p-methylphenyl thioglycoside (STol) donors which are either fully protected or have one hydroxyl group exposed has been quantitatively determined by HPLC in conjunction with the development of a broadly applicable approach fo...	03/25/2003
6518418	Nucleotide sugars Phosphite linked nucleotide sugars, e.g. nucleoside-monophosphite-glycosides, are synthesized using phosphoramiditing agents. The success of the synthetic method is largely independent of the choice of sugar and of nucleotide. The phosphite linked nu...	02/11/2003
6485930	Mannosyl transfer with regeneration of GDP-mannose A one-pot glycosylation reaction is disclosed in which a mannosyl (Man) group is enzymatically transferred to an acceptor molecule. The starting glycoside is a mannosyl 1-phosphate that is enzymatically converted to its GDP derivative via UTP and a pyroph...	11/26/2002
6462193	Hydroxyazepanes as inhibitors of glycosidase and HIV protease Hydroxyazepanes display inhibitory activity with respect to glycosidase, with Ki values from-moderate to low micromolar range. Benzyl and 3,6-dibenzyl derivatives of hydroxyazepanes display inhibitory activity with respect to HIV protease. Thes...	10/08/2002
6423834	KDO aldolase and condensation reactions employed therewith Aureobacterium barkerei strain KDO-37-2 (ATCC 49977) and KDO aldolase (EC 4.1.2.23) isolated therefrom are disclosed. The KDO aldolase is further disclosed to have a broad substrate specificity with respect to its reverse reaction, i.e. the condensation o...	07/23/2002
6353095	Ketoaldonic acids having formed stereogenic centers of R configuration: methods and compositions The present invention provides a ketoaldonic acid such as an octulosonic or nonulosonic acid having a formed stereogenic center of R configuration, as well as methods of synthesizing the same....	03/05/2002
6319695	Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose This invention contemplates improved methods of enzymatic production of carbohydrates especially fucosylated carbohydrates. Improved syntheses of glycosyl 1- or 2-phosphates using both chemical and enzymatic means are also contemplated. The phosphorylated...	11/20/2001
6255088	Enzymatic sulfation of biomolecules Enzymatic sulfations of biomolecules catalyzed by 3'-phosphoadenosine-5'-phosphosulfate (PAPS) dependent sulfotransferases are enhanced by coupling the sulfation reaction an enzymatic regeneration of PAPS. The PAPS is enzymatically regenerated from its hy...	07/03/2001
6120997	Nucleic acid binders having an hydroxyamine motif The invention relates to the combination of hydroxyamines with nucleic acid binding motifs to generate molecules and libraries of molecules targeting specific nucleic acid sequences. In particular, a series of libraries are constructed which contain hydro...	09/19/2000
6111084	Fuopeptide mimetics Bioactive fucopeptides and libraries of fucopeptides having advanced activities against P-selectin as sialyl Lewis X mimetics with IC50 values in the low mM range are synthesized by solid phase synthesis using para-acyloxymethylenzlidene acetal...	08/29/2000
6096784	Inhibitors of oleamide hydrolase Inhibitors of oleamide hydrolase, responsible for the hydrolysis of an endogenous sleep-inducing lipid (1, cis-9-octadecenamide) were designed and synthesized. The most potent inhibitors possess an electrophilic carbonyl group capable of reversibly formin...	08/01/2000
5981267	Enantioselection of amines using homocarbonates with hydrolase Racemic amines are enzymically converted by enantioselective carbamation to produce to chiral carbamates. Simple homocarbonates employed as substrates. The chiral carbamates may then be deprotected to yield the original amine in a chiral form. Alternative...	11/09/1999
5962660	Sialyl Lewis X mimetics incorporating fucopeptides Sialyl Lewis X mimetics incorporating fucopeptides are synthesized and shown to mimic the configuration and essential functional groups of sialyl Lewis X in space. The fucopeptides exhibit substantially the same biological activity as sialyl Lewis X in th...	10/05/1999
5876981	Transglycosylation reactions employing ଲ-galactosidase ଲ-Galactosides are synthesized using a transglycosylation reaction catalyzed by ଲ-galactosidase. The reaction employs a carbohydrate donor having a glycosidic leaving group attached to its anomeric carbon and an oxo group attached to the C-6 c...	03/02/1999
5856537	Inhibitors of oleamide hydrolase Inhibitors of oleamide hydrolase, responsible for the hydrolysis of an endogenous sleep-inducing lipid (1, cis-9-octadecenamide) were designed and synthesized. The most potent inhibitors possess an electrophilic carbonyl group capable of reversibly formin...	01/05/1999
5854391	Glycosylation of peptides using glycosyl phosphite reagents A method for synthesizing glycosylated peptides employs a blocked carbohydrate donor and a blocked peptide acceptor. The carbohydrate donor includes an acid labile phosphite leaving group attached to the anomeric carbon. The blocked peptide acceptor inclu...	12/29/1998
5837862	Sialyl Lewis X mimetics incorporating mannopeptides Sialyl Lewis X mimetics based on mannose glycosides are synthesized and shown to mimic the configuration and essential functional groups of sialyl Lewis X in space. The mannose based mimetics exhibit comparable biological activity as sialyl Lewis X in the...	11/17/1998
5830871	Inhibitors of E-, P- and L-selectin binding Inhibitors of E-, P- and L-selectin binding are synthesized by an aldol addition reaction between a glycoside aldehyde precursor and dihydroxyacetone phosphate or a derivative thereof. The addition reaction is catalyzed by aldolase. The inhibitors exhibit...	11/03/1998
5770407	Process for preparing nucleotide inhibitors of glycosyltransferases Nucleotide linked 2-deoxy-2-fluoroglycosides are employed as potent competitive inhibitors of glycosyltransferases. More particularly, uridine-5'-diphospho-2-deoxy-2-fluoro-galactose (UDP-2F-Gal), guanidine-5'-diphospho-2-deoxy-2-fluoro-L-fucose (GDP-2F-F...	06/23/1998
5766887	Synthesis of 9-0-acetyl N-acetylneuraminic acid oligosaccharides Regioselective acetylation of the 9-hydroxyl group on N-acetylneuraminic acid is achieved enzymatically for producing oligosaccharides which contain a terminal N-acetylneuraminic acid moiety. This method provides access to O-acylated disialogangliosides a...	06/16/1998
5614615	Sialyl Lewis X mimetics incorporating fucopeptides Sialyl Lewis X mimetics incorporating fucopeptides are synthesized and shown to mimic the configuration and essential functional groups of sialyl Lewis X in space. The fucopeptides exhibit substantially the same biological activity as sialyl Lewis X in th...	03/25/1997
5596005	Omega-deoxy-azasugars Omega-deoxy-azapyranose compounds, processes of making and using the same are disclosed, as are a process of making omega-deoxy-azafuranose compounds....	01/21/1997

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Inventor: Chi-Huey Wong