Inventor: Abraham J. Domb

Address: Efrat, IL
No. of patents: 23
Last patent issue date: 04/05/2011

Number	Title	Issue Date
7919113	Dispersible concentrate lipospheres for delivery of active agents A formulation containing one or more lipophilic agents, methods of making and using the formulation are described herein. The formulation is formed by adding a pre-suspension concentrate composition to an aqueous medium. Upon contact with the aqueous medium, a solid...	04/05/2011
7749539	Polymeric formulations for drug delivery Poly(ester-anhydrides) or polyesters formed from ricinoleic acid and natural fatty diacids and their method of preparation and its use for delivering bioactive agents including small drug molecules, peptides and proteins, DNA and DNA complexes with cationic lipids o...	07/06/2010
7732404	Pro-nanodispersion for the delivery of cyclosporin A novel cyclosporine formulation, which is a pro-nanodispersion at room temperature, featuring solid particles of a relatively large particle size (at least about 150 nm) and yet which is a nanodispersion at body temperature. ...	06/08/2010
7297347	Polyanhydrides The invention provides polyanhydrides with aliphatic hydrocarbon terminals having ester or amide bonds. ...	11/20/2007
7026290	Dispersible concentrate for the delivery of cyclosprin A formulation for the administration of a cyclosporin. This formulation features a hydrophilic solvent which is characterized by being a lower alkyl ester of hydroxyalkanoic acid; and a surfactant, preferably a combination of a surfactant with a high HLB (hydrophili...	04/11/2006
7001891	Biodegradable polycation composition for delivery of an anionic macromolecule The present invention provides a biodegradable polycation composition for delivery of an anionic macromolecule, comprising a polysaccharide chain having an amount of saccharide units ranging from 2 to 2000 and at least one grafted oligoamine per 5 saccharide units, ...	02/21/2006
6958325	Cationic polysaccharide compositions The invention provides a polycation composition comprising a polysaccharide chain having an amount of saccharide units ranging from 2 to 2000, at least one oligoamine directly grafted to said polysaccharide chain per each segment of 5 saccharide units, wherein said ...	10/25/2005
6662805	Method for composite cell-based implants This invention is a method for the implantation of a combination of cells or cell-microcarrier aggregates wherein one component comprises a solid implantable construct and a second component comprises an injectable formulation. For example, in one embodim...	12/16/2003
6637437	Cell-culture and polymer constructs The invention is directed to the culture of cells, and particularly chondrocytes for purpose of tissue replacement. The cells are cultured on polymer constructs. Integren expression is used as a measure of chondrocyte viability. Chondrocytes are obtained ...	10/28/2003
6514522	Polymer constructs Polysaccaride polymers are employed in various medical applications. For example, chitosan--arabinogalactan and polysaccharide amine polymers are disclosed. The polymers can be used to prevent wound adhesion, to provide scaffolds for tissue transplantatio...	02/04/2003
6378527	Cell-culture and polymer constructs Cells grown on a microcarrier are separated from the microcarrier by enzymatically digesting the microcarrier. More specifically, chondrocytes may be grown on dextran microcarrier beadlets and then the beadlets digested using dextranase to separate the ch...	04/30/2002
6365173	Stereocomplex polymeric carriers for drug delivery A polymeric carrier for delivery of bioactive or bioreactive molecules is provided, including a stereocomplex of one or more biocompatible polymers and having incorporated on or within the complex the molecules to be delivered. In a preferred embodiment, ...	04/02/2002
6011008	Conjugates of biologically active substances A method for producing a water-soluble polysaccharide conjugate of an oxidation-sensitive substance is described. The method comprises the following steps: (a) activating the polysaccharide to a dialdehyde by periodate oxidation; (b) purifying the dialdeh...	01/04/2000
6007845	Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers Particles are provided that are not rapidly cleared from the blood stream by the macrophages of the reticuloendothelial system, and that can be modified to achieve variable release rates or to target specific cells or organs. The particles have a core of ...	12/28/1999
5846565	Controlled local delivery of chemotherapeutic agents for treating solid tumors A method and devices for localized delivery of a chemotherapeutic agent to solid tumors, wherein the agent does not cross the blood-brain barrier and is characterized by poor bioavailability and/or short half-lives in vivo, are described. The devices cons...	12/08/1998
5695458	Anti-infective polymer-iodine coating for blood collection and delivery systems A body fluid collection, storage and transfusion system which contains a polymer-iodine coating to destroy toxic microorganisms. The system is intended to be used to disinfect blood or blood products, as well as urine, wound exudates, serum, plasma, drain...	12/09/1997
5651986	Controlled local delivery of chemotherapeutic agents for treating solid tumors A method and devices for localized delivery of a chemotherapeutic agent to solid tumors, wherein the agent does not cross the blood-brain barrier and is characterized by poor bioavailability and/or short half-lives in vivo, are described. The devices cons...	07/29/1997
5630978	Preparation of biologically active molecules by molecular imprinting A method for preparing mimics of a wide variety of drugs and other biologically active molecules using molecular imprinting techniques, and the mimics produced thereby, is disclosed. Specifically, the mimic is designed by: (i) polymerization of functional...	05/20/1997
5626862	Controlled local delivery of chemotherapeutic agents for treating solid tumors A method and devices for localized delivery of a chemotherapeutic agent to solid tumors, wherein the agent does not cross the blood-brain barrier and is characterized by poor bioavailability and/or short half-lives in vivo, are described. The devices cons...	05/06/1997
5578325	Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers Injectable particles are provided that are not rapidly cleared from the blood stream by the macrophages of the reticuloendothelial system, and that can be modified as necessary to achieve variable release rates or to target specific cells or organs as des...	11/26/1996
5567685	Water-Soluble polyene conjugate A method for producing a substantially stable water-soluble polysaccharide conjugate of a polyene antibiotic is described. The method comprises the following steps: (a) activating the polysaccharide to a dialdehyde by periodate oxidation; (b) purifying th...	10/22/1996
5437656	Method and device for inhibiting H.I.V. hepatitis B and other viruses and germs when using a needle, scalpel and other sharp instrument in a medical environment An anti-infective coating for a sharp-edged metal instrument. The coating is insoluble in a biological medium and is bound to the metal instrument such as needles and scalpel blades. The coating is a biocompatible, non-hydrogel polymer. One embodiment is ...	08/01/1995
5344411	Method and device for inhibiting HIV, hepatitis B and other viruses and germs when using a catheter in a medical environment An anti-infective coating for a catheter or other medical device. The coating is insoluble in a biological medium and is bound to the surfaces of the catheter. The coating is a biocompatible, non-hydrogel polymer. One embodiment is a coating on the cathet...	09/06/1994

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Inventor: Abraham J. Domb