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| Application No. | Application Title | Issue Date |
| 20100261160 | Methods of screening for modulators of cell proliferation and methods of diagnosing cell proliferation states Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and mol... | 10/14/2010 |
| 20080182271 | Methods for screening and therapeutic applications of kinesin modulators The present invention relates to protein modulators, especially modulators of kinesin bioactivities. The present invention provides methods for screening protein modulators, e.g., kinesin modulators that bind to a region of a kinesin and/or that modulate kinesin bioacti... | 07/31/2008 |
| 20070259390 | High throughput sarcomeric assay The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts. ... | 11/08/2007 |
| 20070254310 | Compositions and assays utilizing ADP or phosphate for detecting protein modulators Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throug... | 11/01/2007 |
| 20060094074 | Methods for screening and therapeutic applications for kinesin modulators The present invention relates to protein modulators, especially modulators of kinesin bioactivities. The present invention provides methods for screening protein modulators, e.g., kinesin modulators that bind to a region of a kinesin and/or that modulate kinesin bioacti... | 05/04/2006 |
| 20060024786 | WASP and N-WASP constructs and methods of expressing such constructs WASP and N-WASP proteins are provided that can be expressed in soluble form, including fusion proteins that contain full-length WASP and N-WASP. The proteins retain at least partial activity of full length WASP or N-WASP and some of the proteins fully recapitulate the a... | 02/02/2006 |
| 20060014266 | Purification of Arp2/3 complex and compositions containing purified Arp2/3 complex Methods for rapidly purifying Arp2/3 complex are provided. Compositions containing purified Arp2/3 complex that is characterized by having equal stoichiometry of the subunits are also disclosed. ... | 01/19/2006 |
| 20060003399 | High throughput actin polymerization assay Methods for assaying for actin polymerization are described, as are the use of the assays to screen for modulators of actin polymerization. The screening methods can be utilized to identify active agents that interact with actin, the polymerization state of actin and ot... | 01/05/2006 |
| 20050266511 | High throughput sarcomeric assay The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts. ... | 12/01/2005 |
| 20050191631 | Plus end-directed microtubule motor required for chromosome congression The invention provides isolated nucleic acid and amino acid sequences of Xenopus CENP-E (XCENP-E), antibodies to XCENP-E, methods of screening for CENP-E modulators using biologically active CENP-E, and kits for screening for CENP-E modulators. ... | 09/01/2005 |
| 20050130143 | Human smooth muscle myosin heavy chain The invention provides novel compositions, methods, and uses of hSMMyHC polypeptides and polynucleotides. ... | 06/16/2005 |
