Did You Know...
...that the x-ray was discovered purely by accident? When German physicist Wilhelm Konrad von Roentgen was experimenting with cathode rays in 1895, he put an activated Crookes tube in a book and went out to lunch. When he returned, he discovered that a key that had also been placed in the book showed up as an image on the developed film!
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| Application No. | Application Title | Issue Date |
| 20100055184 | HYDROGELS FOR VOCAL CORD AND SOFT TISSUE AUGMENTATION AND REPAIR The present invention provides hydrogels and compositions thereof for vocal cord repair or augmentation, as well as other soft tissue repair or augmentation (e.g., bladder neck augmentation, dermal fillers, breast implants, intervertebral disks, muscle-mass). The hydrog... | 03/04/2010 |
| 20100036084 | BIODEGRADABLE POLY(BETA-AMINO ESTERS) AND USES THEREOF Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-conta... | 02/11/2010 |
| 20100022680 | Microfluidic Synthesis of Organic Nanoparticles The present invention provides microfluidic systems and methods for the production of particles (e.g., nanoparticles) for drug delivery. The present invention provides microfluidic devices useful for production of particles by nanoprecipitation. The present invention pr... | 01/28/2010 |
| 20100015068 | Methods and Compositions For Altering Biological Surfaces Compositions, methods and kits are provided for altering the properties of a biological surface using particles such as, for instance, calcium based particles in combination with an agent that binds to the biological surface. Properties such as color, sheen, texture, st... | 01/21/2010 |
| 20090298710 | System for Screening Particles Screening of a library of particles in vivo and/or in vitro using Polyplex Iterative Combinatorial Optimization (PICO) allows for the design of particles for targeting a specific organ, tissue (e.g., cancer), or cell. Particles may, for example, include different target... | 12/03/2009 |
| 20080281405 | Highly convertible endolumenal prostheses and methods of manufacture Endolumenal prostheses that readily and extensively convert from a delivery configuration to a deployed configuration are disclosed. Endolumenal prostheses may be fabricated from one or more shape memory polymers, a high modulus elastomer, a polymer that is both elastom... | 11/13/2008 |
| 20080268063 | Coated Controlled Release Polymer Particles as Efficient Oral Delivery Vehicles for Biopharmaceuticals A composition for delivering an active agent to a patient. The composition includes a polymer core encapsulating the active agent and a mucoadhesive coating disposed about the core. The polymer may include covalently linked poly(ethylene glycol) chains, and the mucoadhe... | 10/30/2008 |
| 20080255267 | Disposable Medical Supplies From Hydrolytically Biodegradable Plastics Hydrolytically degradable polymers in the form of biodegradable disposable medical devices for use in medicine and laboratories such as syringes, test tubes, catheters, tubing, trays, medical fabrics, and gloves are described. The devices are formed in whole or in part ... | 10/16/2008 |
| 20080253971 | Particles for inhalation having sustained release properties The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates... | 10/16/2008 |
| 20080248017 | METHODS AND DEVICES FOR THE SUSTAINED RELEASE OF MULTIPLE DRUGS The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments f... | 10/09/2008 |
| 20080193536 | Cell-Laden Hydrogels The present invention provides cell-laden hydrogels and hydrogel assemblies thereof for use in tissue engineering. The invention provides microscale hydrogels (i.e. microgels) having greatest dimensions ranging between about 1 μm and 1000 μm. The present invention pro... | 08/14/2008 |
| 20080182240 | Uses And methods of making Microarrays of Polymeric biomaterials A microarray of polymeric biomaterials is provided. Specifically, a microarray of polymeric biomaterials that comprises a base with a cytophobic surface, and a plurality of discrete polymeric biomaterial elements bound to the cytophobic surface, is provided. Preferably ... | 07/31/2008 |
| 20080172043 | MICROCHIP RESERVOIR DEVICES USING WIRELESS TRANSMISSION OF POWER AND DATA Devices and methods are provided for wirelessly powering and/or communicating with implanted medical devices used for the controlled exposure and release of reservoir contents, such as drugs or sensors. The device may include a substrate having a plurality of reservoirs... | 07/17/2008 |
| 20080145338 | CROSSLINKED, DEGRADABLE POLYMERS AND USES THEREOF Acrylate-terminated poly(beta-amino esters) are cross-linked to form materials useful in the medical as well as non-medical field. The polymeric starting material is combined with a free radical initiator, either a thermal initiator or a photoinitiator, and the mixture ... | 06/19/2008 |
| 20080115559 | Method for Operating a Reservoir-Based Sensor Device Methods for operating a sensor device are provided, which may include (a) providing at a site (e.g., implanting in a patient) a device which comprises at least first and second reservoirs, a first sensor and corresponding first reference sensor located within the first ... | 05/22/2008 |
| 20080115361 | Method for Making Reservoir-Based Sensor Device Methods are provided for making a reservoir-based sensor device. The method may include fabricating a first substrate portion which comprises an upper surface, an opposed lower surface, a plurality of through holes defining reservoirs between said upper surface and said... | 05/22/2008 |
| 20080081074 | Polymers for functional particles The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of emb... | 04/03/2008 |
| 20080069857 | Compositions And Methods For Inhibiting Adhesions The present invention provides compositions and methods for inhibiting adhesions. The methods involve administering solutions containing hydrogel precursors such as polysaccharide derivatives, e.g., derivatives of hyaluronic acid, cellulose, or dextran, to a subject at ... | 03/20/2008 |
| 20080071252 | METHOD OF ACTUATING IMPLANTED MEDICAL DEVICE Methods are provided for medical treatment or diagnosis of a patient. The method includes implanting into the patient a device which comprises (i) a substrate in which at least one reservoir is located and covered by a first reservoir cap, (ii) a drug or sensor located ... | 03/20/2008 |
| 20080051766 | Method for Operating Microchip Reservoir Device A method is provided for operating a device for the containment and controlled release or exposure of a chemical substance. The method includes (i) providing a device which includes a substrate having a plurality of reservoirs, at least one chemical substance stored in ... | 02/28/2008 |
| 20080047926 | Method for Making Microchip Reservoir Device Methods are provide for fabricating a microchip device having containment reservoirs. In one embodiment, the method includes providing a substrate; forming a plurality of reservoirs in the substrate, each reservoir having an opening in a surface of the substrate; fabric... | 02/28/2008 |
| 20070299385 | DEVICE FOR THE CONTROLLED EXPOSURE OF RESERVOIR-BASED SENSORS Devices are provided for the controlled exposure of a sensor or sensor component. The device may include a substrate; at least one reservoir provided in the substrate; at least one sensor or sensor component located in the at least one reservoir; at least one reservoir ... | 12/27/2007 |
| 20070266801 | Reversible Sealing of Microfluidic Arrays Channel arrays are reversibly disposed over an array of microwells to deliver materials, for example, cells, to the microwells. ... | 11/22/2007 |
| 20070196433 | Methods and devices for the sustained release of multiple drugs The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments f... | 08/23/2007 |
| 20070042491 | Amplification of cell populations from embryonic stem cells Culturing embryonic stem cells without the use of embryoid bodies leads to a increase in the frequency of predetermined cell types. ... | 02/22/2007 |
| 20070036855 | Soft polylactides Biodegradable polymeric compositions that are liquids or pastes at temperatures below 37° C. are described. Immersion of the compositions in aqueous medium, such as body fluids, increases the viscosity of the composition resulting in the formation of a semisolid materi... | 02/15/2007 |
| 20070014738 | Particles for inhalation having sustained release properties The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates... | 01/18/2007 |
| 20070005139 | Tissue engineered tendons and ligaments Connective tissue, including neo-tendons and ligaments, has been constructed using biodegradable synthetic scaffolds seeded with tenocytes. The scaffolds are preferably formed from biodegradable fibers formed of a polymer such as polyglycolic acid-polylactic acid copoly... | 01/04/2007 |
| 20060276416 | Methods and compositions for treating flushing and drug induced weight gain Provided herein are methods and compositions for treating and/or preventing flushing and/or weight gain. Methods may comprise modulating the activity or level of a sirtuin, such as SIRT1 or Sir2. Exemplary embodiments include methods and compositions for counteracting d... | 12/07/2006 |
| 20060263033 | Switchable surfaces A substrate having a surface with reversibly switchable properties. The surface comprises a nanolayer of a material that switches from a first conformation stateto a second conformation state when an external stimulus is applied. When the nanolayer is in the first confo... | 11/23/2006 |
| 20060237080 | Patterned surfaces and polymeric microstructures within robust microfluidic channels Microfluidic channel. The channel includes a microfluidic mold defining a channel and a substrate including patterned regions. The microfluidic mold is in conformal contact with the substrate to form an irreversible seal. The patterned regions are adapted to immobilize ... | 10/26/2006 |
| 20060228404 | Compositions and methods for treatment of hypertrophic tissues The present invention provides compositions and methods for treatment of conditions and diseases associated with excessive or inappropriate noncancerous tissue growth. In certain embodiments of the invention the compositions and methods are used for treatment of benign ... | 10/12/2006 |
| 20060198827 | Engineering vascularized muscle tissue A tissue engineered construct. The construct includes endothelial cells, muscle cells, and a three-dimensional support matrix on which the endothelial cells and the myoblasts are seeded. ... | 09/07/2006 |
| 20060154894 | Biologically active surfaces and methods of their use The invention relates to the immobilization of polysaccharides on a substrate. In particular, the invention relates to biologically active surfaces formed by the immobilization of glycosaminoglycans on a substrate. The invention also provides biologically active surface... | 07/13/2006 |
| 20060142794 | Self-expanding device for the gastrointestinal or urogenital area Devices for treatments of diseases and disorders associated with the gastrointestinal tract, especially the stomach, or urinogenital tract are described herein. Initially, the device is in a temporary form which is suitable for oral or rectal administration. After expos... | 06/29/2006 |
| 20060141000 | Porous biodegradable polymeric materials for cell transplantation Polymeric materials are used to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the matrix... | 06/29/2006 |
| 20060088579 | Transdermal drug delivery systems One aspect of the invention provides a transdermal delivery system including a drug formulated with a transport chaperone moiety that reversibly associates with the drug. The chaperone moiety is associated with the drug in the formulation so as to enhance transport of t... | 04/27/2006 |
| 20060083711 | Methods and products related to the intracellular delivery of polysaccharides The invention relates, in part, to methods and compositions for the intracellular delivery of polysaccharides. In particular, the methods and compositions relate to the intracellular delivery of glycosaminoglycans, such as heparin. The invention in other aspects relates... | 04/20/2006 |
| 20050276835 | Photo-reactive polymer platform for use in biomedical devices A polymer having the following structure: where m is 0 to 10000 and n is 0 to 10000. The polymer may be used in a coating such as on a biomedical device. The polymer is an adhesion promotor for a drug delivery system wherein the polymer is coated onto a substrate su... | 12/15/2005 |
| 20050265961 | Biodegradable poly(beta-amino esters) and uses thereof Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-conta... | 12/01/2005 |