Inventor: Robert S. Langer

Address: Newton, MA
No. of applications: 88
Last application issue date: 01/12/2012

Application No.	Application Title	Issue Date
20120009222	MODULATION OF THE IMMUNE RESPONSE The present invention provides lipidoids that can be used to modulate the immune response in a subject. Lipidoids are prepared by the conjugate addition of an amine to an acrylate to acrylamide. The lipidoids form complexes or particles with an immunostimulatory polynuc...	01/12/2012
20110293703	AMINOALCOHOL LIPIDOIDS AND USES THEREOF Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic ...	12/01/2011
20110280912	DEGRADABLE POLYMER NANOSTRUCTURE MATERIALS This invention relates generally to composites comprising a plurality of nanostructures, and methods of making the same. In some embodiments, the composites further comprise a polymer. In some embodiments, the composites may have desirable properties such as, for exampl...	11/17/2011
20110268805	ADJUVANT INCORPORATION IN IMMUNONANOTHERAPEUTICS The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that compr...	11/03/2011
20110268804	TARGETING OF ANTIGEN PRESENTING CELLS WITH IMMUNONANOTHERAPEUTICS The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that compr...	11/03/2011
20110212027	RADIATIVE HEATING FOR DRUG DELIVERY AND OTHER APPLICATIONS The present invention generally relates to systems and methods for releasing a releasable species from an article using an external trigger, for example, using microwave radiation or other forms of radiation, e.g., radiofrequency radiation. Such systems and methods may ...	09/01/2011
20110212163	MAGNETIC HEATING FOR DRUG DELIVERY AND OTHER APPLICATIONS The present invention generally relates to systems and methods for releasing a compound from an article using an external trigger, for example, magnetic fields. One aspect of the invention is generally directed to an article containing a magnetically-susceptible materia...	09/01/2011
20110172587	METHOD AND SYSTEM FOR DRUG DELIVERY TO THE EYE Methods and systems are provided for delivering drug to the eye. The method and system may include implanting into the eye a device which comprises two or more discrete reservoirs, each reservoir containing a drug; and directing focused light to the implanted device to ...	07/14/2011
20110166060	TYMPANIC MEMBRANE PERMEATING EAR DROPS AND USES THEREOF The present invention provides compositions and methods for noninvasive delivery of therapeutic agents across an intact tympanic membrane. For example, the compositions include a penetration enhancer which increases the flux of a therapeutic agent (e.g., antibiotic) acr...	07/07/2011
20110163469	HIGH-THROUGHPUT FABRICATION OF MICROPARTICLES The high-throughput fabrication of microparticles based on the double emulsion/solvent evaporation technique for screening and optimizing microparticle formulations for particular characteristics allows for the preparation of multiple microparticle formulations in paral...	07/07/2011
20110135575	METALLOPROTEIN MRI CONTRAST AGENTS AND RELATED METHODS The present invention generally relates to Magnetic Resonance Imaging (MRI) analysis of the location, presence, and/or quantity of a particular molecule or material. In some embodiments, the invention relates to compositions and methods for determination of an analyte, ...	06/09/2011
20110125107	METHODS AND DEVICES FOR SENSING TISSUES AND TISSUE COMPARTMENTS An apparatus provides feedback regarding the material in which tip of the apparatus is located as the tip is advance into matter of varying resistances. The apparatus responds to a change in pressure, force, or other parameter such that when the tip reaches matter of a ...	05/26/2011
20110077216	COMPOSITIONS AND METHODS FOR THE TREATMENT OF ATHEROSCLEROSIS AND OTHER RELATED DISEASES The present invention provides compositions and methods for the treatment of atherosclerosis and other related diseases. In some embodiments, a method comprises providing a composition and forming a coating of the composition on at least a portion of the interior and/or...	03/31/2011
20110065807	PH SENSITIVE BIODEGRADABLE POLYMERIC PARTICLES FOR DRUG DELIVERY The present invention generally relates to polymers and particles, such as nanoparticles. The particles and polymers generally include one or more buffering components. Additionally, the particles and polymers may include two or more components that impart useful proper...	03/17/2011
20110052697	Aptamer-Directed Drug Delivery The present invention provides systems, methods, and compositions for targeted delivery of a therapeutic agent organs, tissues, cells, extracellular matrix components, and intracellular compartments. The present invention provides a complex comprising a therapeutic or d...	03/03/2011
20110045049	IMMUNOMODULATING COMPOSITIONS AND METHODS OF USE This invention is directed to β-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The β-1-6-glucans of certain embodiments of the invention are enriched for O-acetylated groups and/or conjugated to a ...	02/24/2011
20110027172	DRUG DELIVERY SYSTEM FOR PHARMACEUTICALS AND RADIATION The present invention provides a drug delivery system for delivery of an agent and a radiopharmaceutical agent. The drug delivery system may specifically target an organ, tissue, cells, extracellular matrix, or intracellular compartment. Typically, the drug delivery sys...	02/03/2011
20110008277	POLYOL-BASED POLYMERS The present invention provides inventive polyol-based polymers, materials, pharmaceutical compositions, and methods of making and using the inventive polymers and materials. In certain aspects of the invention, an inventive polymer corresponds to a polymer depicted belo...	01/13/2011
20110009641	Amine-containing lipids and uses thereof Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting mater...	01/13/2011
20100331234	AMINOALCOHOL LIPIDOIDS AND USES THEREOF Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic ...	12/30/2010
20100323199	POLYMERS FOR FUNCTIONAL PARTICLES The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of emb...	12/23/2010
20100303723	DRUG DELIVERY SYSTEMS USING FC FRAGMENTS The present invention provides drug delivery systems comprising FcRn binding partners (e.g., FcRn binding partner, Fc fragment) associated with a particle or an agent to be delivered. Inventive drug delivery systems allow for binding to the FcRn receptor and transcytosi...	12/02/2010
20100297233	OSCILLATING CELL CULTURE BIOREACTOR Methods and devices for cell or tissue culture are provided. One aspect provides a bioreactor having a gas permeable, closed-loop chamber for cell or tissue culture, and an oscillating means for moving the gas permeable, closed-loop chamber bidirectionally along an axis...	11/25/2010
20100291219	METHODS AND COMPOSITIONS RELATING TO PROGENITOR CELLS The invention provides compositions and methods for harvesting and enriching cells such as connective tissue progenitors cells using stirred bioreactors, and in some embodiments fibrin microcarriers....	11/18/2010
20100273259	SUBSTRATES AND METHODS FOR CULTURING STEM CELLS The present disclosure provides a device and a cell culture system comprising a substrate that generates significant chemical ion signatures adapted for culturing stem cells. This disclosure further provides unique surface properties, such as surface wettability, along ...	10/28/2010
20100269837	MONITORING OF IMPLANTS AND OTHER DEVICES The present invention generally relates to implants and, in particular, to systems and methods for monitoring the condition of an implant within a subject. In some embodiments, an implant may be prepared that contains a tracer. After implantation, the tracer from the im...	10/28/2010
20100256465	DEVICES AND TECHNIQUES ASSOCIATED WITH DIAGNOSTICS, THERAPIES, AND OTHER APPLICATIONS, INCLUDING SKIN-ASSOCIATED APPLICATIONS The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. ...	10/07/2010
20100233251	Vaccine Nanotechnology The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at lea...	09/16/2010
20100233132	FORMATION OF VASCULAR NETWORKS USING EMBRYONIC STEM CELLS In various aspects, provided are methods for providing CD34⁺ cells from embryoid bodies and stimulating these cells to give rise to endothelial-like and/or smooth muscle-like cells. In various embodiments are provided methods that produce endothelial-like and...	09/16/2010
20100234244	USES AND METHODS OF MAKING MICROARRAYS OF POLYMERIC BIOMATERIALS A microarray of polymeric biomaterials is provided. Specifically, a microarray of polymeric biomaterials that comprises a base with a cytophobic surface, and a plurality of discrete polymeric biomaterial elements bound to the cytophobic surface, is provided. Preferably ...	09/16/2010
20100215708	COATING OF DEVICES WITH EFFECTOR COMPOUNDS This invention is directed to substrates, materials and devices coated with a gel, foam, film, particle or composition comprising a polymei solvent and effector compounds attached thereto, processes of producing the same, and methods of use thereof, of in, inter-alia, b...	08/26/2010
20100196492	ELECTROSTATIC COATING OF PARTICLES FOR DRUG DELIVERY A system for electrostatically coating particles is provided. The system is particularly well suited for coating charged drug delivery particles (e.g., nanoparticles, microparticles) with a coating of opposite charge. The coating may include a targeting moiety such as a...	08/05/2010
20100196481	SPINAL CORD INJURY, INFLAMMATION, AND IMMUNE-DISEASE: LOCAL CONTROLLED RELEASE OF THERAPEUTIC AGENTS A drug delivery system is provided for treatment of oxidative stress. The drug delivery system can include a therapeutic agent and a matrix. The therapeutic agent can include an antioxidant or steroid. The matrix can include a hydrogel, particle, microparticle, or nanop...	08/05/2010
20100144845	OLIGONUCLEOTIDE SYSTEMS FOR TARGETED INTRACELLULAR DELIVERY The present invention provides methods for deriving oligonucleotides for specific internal delivery to one or more target cell types (e.g., cancer cells). The method generally includes selecting at least once with a target cell type to provide a plurality of internalizi...	06/10/2010
20100137696	MEDICAL DEVICE WITH RESERVOIR-BASED SENSORS A medical device is provided which may include a reservoir which has an opening and contains a sensor; a reservoir cap closing off the opening to isolate the sensor from an environmental component outside the reservoirs, the reservoir cap being impermeable to the enviro...	06/03/2010
20100112026	SURFACES, METHODS AND DEVICES EMPLOYING CELL ROLLING In various aspects, the present invention provides surfaces and materials for cell rolling applications, methods of making such surfaces and materials, and devices having such surfaces and materials. In some embodiments, the present invention provides surfaces with at l...	05/06/2010
20100055184	HYDROGELS FOR VOCAL CORD AND SOFT TISSUE AUGMENTATION AND REPAIR The present invention provides hydrogels and compositions thereof for vocal cord repair or augmentation, as well as other soft tissue repair or augmentation (e.g., bladder neck augmentation, dermal fillers, breast implants, intervertebral disks, muscle-mass). The hydrog...	03/04/2010
20100036084	BIODEGRADABLE POLY(BETA-AMINO ESTERS) AND USES THEREOF Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-conta...	02/11/2010
20100022680	Microfluidic Synthesis of Organic Nanoparticles The present invention provides microfluidic systems and methods for the production of particles (e.g., nanoparticles) for drug delivery. The present invention provides microfluidic devices useful for production of particles by nanoprecipitation. The present invention pr...	01/28/2010
20100015068	Methods and Compositions For Altering Biological Surfaces Compositions, methods and kits are provided for altering the properties of a biological surface using particles such as, for instance, calcium based particles in combination with an agent that binds to the biological surface. Properties such as color, sheen, texture, st...	01/21/2010

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Inventor: Robert S. Langer