William F. Semple, a dentist, was awarded the first US Patent on chewing gum in 1869. His recipe contained powdered chalk.
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| Number | Title | Issue Date |
| 6593480 | Glucocorticoid receptor antagonists for treatment of diabetes Compounds of formula I ##STR1## are useful for treating type II diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, composi... | 07/15/2003 |
| 6583180 | Glucocorticoid receptor modulators Compounds of formula (I) ##STR1## or pharmaceutically acceptable salts thereof are novel glucocorticoid receptor modulators and are useful for treating type II diabetes in a mammal.... | 06/24/2003 |
| 6579882 | Cell adhesion-inhibiting antiinflammatory compounds Compounds having Formula I ##STR1## are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.... | 06/17/2003 |
| 6329534 | Glucocorticoid receptor antagonists for treatment of diabetes Compounds of formula I ##STR1## are useful for treating type II diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, composi... | 12/11/2001 |
| 6232320 | Cell adhesion-inhibiting antiinflammatory compounds Compounds having Formula I ##STR1## are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.... | 05/15/2001 |
| 5185364 | Aminomethyl-chroman and -thiochroman compounds The present invention includes compounds represented by the formula: ##STR1## wherein X is O or S; R1 and R2 are independently selected from the group consisting of hydrogen, hydroxy, halo, loweralkoxy, thioalkoxy and loweralkyl; or ... | 02/09/1993 |
| 5140039 | Aminomethyl-thiochroman compounds The present invention includes compounds represented by the formula: ##STR1## wherein X is O or S; R1 and R2 are independently selected from the group consisting of hydrogen, hydroxy, halo, loweralkoxy, thioalkoxy and loweralkyl... | 08/18/1992 |
| 5089519 | Aminomethyl-chroman compounds The present invention includes compounds represented by the formula: ##STR1## wherein X is O or S; R1 and R2 are independently selected from the group consisting of hydrogen, hydroxy, halo, loweralkoxy, thioalkoxy and loweralkyl; or ... | 02/18/1992 |
| 4505932 | Method of producing 2 -adrenergic receptor agonist activity A method of producing 댒 -adrenergic receptor agonist activity by contacting an 댒 -adrenergic receptor with an effective amount of a compound of the formula: ##STR1## wherein R1, R2, R3 | 03/19/1985 |
| 4500543 | Substituted 1-aminomethyl-phthalans Disclosed herein are 1-aminomethyl-phthalans represented by the formula ##STR1## wherein R, R1, and R2 are independently selected from hydrogen, hydroxy, loweralkoxy of 1 to 3 carbon atoms, loweralkenyloxy of 1 to 3 carbon atoms... | 02/19/1985 |
| 4473586 | Aminoalkyl dihydronaphthalenes Disclosed herein are 1-aminoalkyl-3,4-dihydronaphthalenes represented by the formula ##STR1## wherein n is 1 or 2; R, R1, and R2 are independently selected from hydrogen, hydroxy, loweralkoxy of 1 to 3 carbon atoms, loweral... | 09/25/1984 |
| 4234594 | Pyrazolyl amino imidazolines as antihypertensive agents Described is a method of treating hypertensive by administering to mammalian patients compounds of the formula ##STR1## wherein R1 and R2 are hydrogen, loweralkyl, lowercycloalkyl, aralkyl, aryl, pyridyl, isoquinolyl, phthalazin... | 11/18/1980 |
| 4226877 | Pyrazoles active in the central nervous system Disclosed are pyrazoles of the formula ##STR1## wherein R1 is hydrogen, lower alkyl, or phenyl, R2 is hydrogen or lower alkyl, R3 is alkoxy or hydroxy, R4 is lower alkyl, and the pharmaceutically acceptable... | 10/07/1980 |