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Inventor: Adolfo Garcia-Sastre


Address: New York, NY,
No. of applications: 6
Last application issue date: 11/12/2009

Application No.Application TitleIssue Date
20090280144Recombinant newcastle disease virus RNA expression systems and vaccines
This invention relates to genetically engineered Newcastle disease viruses and viral vectors which express heterologous genes or mutated Newcastle disease viral genes or a combination of viral genes derived from different strains of Newcastle disease virus. The inventio...
11/12/2009
20090203114NOVEL METHODS AND INTERFERON DEFICIENT SUBSTRATES FOR THE PROPAGATION OF VIRUSES
The present invention relates, to novel methods and substrates for the propagation of viruses. The invention relates to IFN-deficient substrates and methods for propagating viruses in these unconventional substrates. In particular, the invention relates to methods of pr...
08/13/2009
20090061521Recombinant negative strand RNA virus expression systems and vaccines
The present invention relates methods of generating infectious negative-strand virus in host cells by an entirely vector-based system without the aid of a helper virus. In particular, the present invention relates methods of generating infectious recombinant negative-st...
03/05/2009
20090053264Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals
The present invention relates, in general, to attenuated negative-strand RNA viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. The invention also re...
02/26/2009
20090028901Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents
The present invention relates, in general, to a screening method for identifying novel viral proteins with interferon antagonizing function using a transfection-based assay, and the use of such proteins in isolating various types of attenuated viruses for the developmen...
01/29/2009
20090010962Genetically Engineered Swine Influenza Virus and Uses Thereof
The present invention relates, in general, to attenuated swine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular, the invent...
01/08/2009
 
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